生物胺对多发性硬化症中 Th17 介导的免疫应答的影响。
The influence of biogenic amines on Th17-mediated immune response in multiple sclerosis.
机构信息
Department of Neurology, Neurosurgery and Medical Genetics of Pirogov Russian National Research Medical University, 117997 Moscow, Russia; Laboratory of Clinical Immunology, National Research Center Institute of Immunology of the Federal Medical-Biological Agency, 115478 Moscow, Russia.
Department of Molecular Pharmacology and Radiobiology of Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
出版信息
Mult Scler Relat Disord. 2018 Apr;21:19-23. doi: 10.1016/j.msard.2018.02.012. Epub 2018 Feb 12.
Biogenic amines are direct mediators of interactions between immune and nervous systems implicated in the pathogenesis of multiple sclerosis (MS). Recently, great attention has been drawn to studying the effects of biogenic amines on Th17-cells, which play one of the central roles in the development of inflammatory lesions in MS. Results of these studies suggest that, depending on the activation of particular receptors, biogenic amines can both enhance and inhibit Th17-cell functions. Based on these data, targeting biogenic amines and their receptors could be explored as a new kind of additional disease-modifying treatment of MS.
生物胺是参与多发性硬化症（MS）发病机制的免疫和神经系统相互作用的直接介质。最近，人们越来越关注研究生物胺对 Th17 细胞的影响，Th17 细胞在 MS 炎症病变的发展中起着核心作用之一。这些研究的结果表明，根据特定受体的激活情况，生物胺既可以增强也可以抑制 Th17 细胞的功能。基于这些数据，针对生物胺及其受体的治疗方法可能会被探索作为 MS 的一种新型的附加疾病修饰治疗方法。
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