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本文引用的文献

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Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice.脂肪特异性蛋白27在脂肪细胞中的特异性缺失会导致高脂饮食喂养小鼠出现肝脂肪变性和胰岛素抵抗。
J Biol Chem. 2015 Jan 30;290(5):3092-105. doi: 10.1074/jbc.M114.605980. Epub 2014 Dec 4.
2
CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis.CIDEC/FSP27受过氧化物酶体增殖物激活受体α调控，在禁食和饮食诱导的肝脂肪变性中起关键作用。
Hepatology. 2015 Apr;61(4):1227-38. doi: 10.1002/hep.27607. Epub 2015 Mar 9.
3
Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis.肝脏富集转录因子CREBH对Fsp27的转录激活促进脂滴生长和肝脂肪变性。
Hepatology. 2015 Mar;61(3):857-69. doi: 10.1002/hep.27371. Epub 2015 Jan 28.
4
Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice.肝组织过氧化物酶体增殖物激活受体γ和肝 X 受体α独立调控遗传性肥胖小鼠肝脏脂质蓄积
FEBS Lett. 2014 Jun 27;588(14):2277-81. doi: 10.1016/j.febslet.2014.05.012. Epub 2014 May 21.
5
Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.肥胖和胰岛素抵抗中肝 X 受体对肝和脂肪的脂生成的相互调节作用。
Cell Metab. 2013 Jul 2;18(1):106-17. doi: 10.1016/j.cmet.2013.04.021.
6
Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. perilipin1 通过激活脂肪细胞中的 Fsp27 促进单泡脂滴形成。
Nat Commun. 2013;4:1594. doi: 10.1038/ncomms2581.
7
Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate.Fsp27/CIDEC 是肝脏在早期禁食期间被 CREB 靶向诱导的基因，其表达受到 FA 氧化率的调节。
J Lipid Res. 2013 Mar;54(3):592-601. doi: 10.1194/jlr.M028472. Epub 2012 Dec 6.
8
Liver X receptor α is involved in the transcriptional regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.肝 X 受体 α 参与 6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶基因的转录调控。
Diabetes. 2012 May;61(5):1062-71. doi: 10.2337/db11-1255. Epub 2012 Mar 13.
9
FSP27 promotes lipid droplet clustering and then fusion to regulate triglyceride accumulation.FSP27 通过促进脂滴聚集，然后融合来调节甘油三酯的积累。
PLoS One. 2011;6(12):e28614. doi: 10.1371/journal.pone.0028614. Epub 2011 Dec 14.
10
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites.Fsp27 通过在脂滴接触部位的脂质交换和转移促进脂滴生长。
J Cell Biol. 2011 Dec 12;195(6):953-63. doi: 10.1083/jcb.201104142. Epub 2011 Dec 5.

脂肪特异性蛋白 27 是肝 X 受体α的一个新的靶基因。

Fat-specific protein 27 is a novel target gene of liver X receptor α.

机构信息

Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

出版信息

Mol Cell Endocrinol. 2018 Oct 15;474:48-56. doi: 10.1016/j.mce.2018.02.006. Epub 2018 Feb 15.

DOI:10.1016/j.mce.2018.02.006
PMID:29454584
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6594021/
Abstract

Fat-specific protein 27 (FSP27) is highly expressed in the fatty liver of genetically obese ob/ob mice and promotes hepatic triglyceride (TG) accumulation. The nuclear hormone receptor liver X receptor α (LXRα) also plays a critical role in the control of TG levels in the liver. The present study demonstrated transcriptional regulation of Fsp27a and Fsp27b genes by LXRα. Treatment with the LXR ligand T0901317 markedly increased Fsp27a and Fsp27b mRNAs in wild-type C57BL/6J and ob/ob mouse livers. A reporter assay indicated that two LXR-responsive elements (LXREs) are necessary for LXRα-dependent induction of Fsp27a and Fsp27b promoter activities. Furthermore, the LXRα/retinoid X receptor α complex is capable of directly binding to the two LXREs both in vitro and in vivo. These results suggest that LXRα positively regulates Fsp27a and Fsp27b expression through two functional LXREs. Fsp27a/b are novel LXR target genes in the ob/ob fatty liver.

摘要

脂肪特异性蛋白 27（FSP27）在遗传性肥胖 ob/ob 小鼠的脂肪肝中高度表达，并促进肝甘油三酯（TG）蓄积。核激素受体肝 X 受体α（LXRα）在肝脏 TG 水平的控制中也起着关键作用。本研究证明了 LXRα对 Fsp27a 和 Fsp27b 基因的转录调控。用 LXR 配体 T0901317 处理，野生型 C57BL/6J 和 ob/ob 小鼠肝脏中的 Fsp27a 和 Fsp27b mRNA 明显增加。报告基因检测表明，两个 LXR 反应元件（LXREs）是 LXRα 依赖诱导 Fsp27a 和 Fsp27b 启动子活性所必需的。此外，LXRα/视黄酸 X 受体α 复合物能够在体外和体内直接结合到两个 LXRE 上。这些结果表明，LXRα 通过两个功能性 LXRE 正向调节 Fsp27a 和 Fsp27b 的表达。Fsp27a/b 是 ob/ob 脂肪肝中 LXR 的新靶基因。