Obis J, Satue M, Alarcia R, Pablo L E, Garcia-Martin E
Departamento de Oftalmología, Hospital Universitario Miguel Servet, Zaragoza, España.
Departamento de Oftalmología, Hospital Universitario Miguel Servet, Zaragoza, España.
Arch Soc Esp Oftalmol (Engl Ed). 2018 May;93(5):231-238. doi: 10.1016/j.oftal.2018.01.004. Epub 2018 Feb 14.
Parkinson's disease (PD) is a neurodegenerative process that affects 7.5 million people around the world. Since 2004, several studies have demonstrated changes in various retinal layers in PD using optical coherence tomography (OCT). However, there are some discrepancies in the results of those studies. Some of them have correlated retinal thickness with the severity or duration of the disease, demonstrating that OCT measurements may be an innocuous and easy biomarker for PD progression. Other studies have demonstrated visual dysfunctions since early phases of the disease. Lastly, the most recent studies that use Swept Source OCT technology, have found choroidal thickness increase in PD patients and provide new information related to the retinal degenerative process in this disease. The aim of this paper is to review the literature on OCT and PD, in order to determine the altered retinal and choroidal parameters in PD and their possible clinical usefulness, and also the visual dysfunctions with higher impact in these patients.
帕金森病（PD）是一种神经退行性疾病，全球约有750万人受其影响。自2004年以来，多项研究利用光学相干断层扫描（OCT）技术证实了帕金森病患者视网膜各层存在变化。然而，这些研究结果存在一些差异。其中一些研究将视网膜厚度与疾病的严重程度或病程相关联，表明OCT测量可能是一种用于帕金森病病情进展的无害且简便的生物标志物。其他研究则显示，在疾病早期阶段就存在视觉功能障碍。最后，最近使用扫频源OCT技术的研究发现，帕金森病患者脉络膜厚度增加，并提供了与该疾病视网膜退行性变过程相关的新信息。本文旨在综述有关OCT与帕金森病的文献，以确定帕金森病患者视网膜和脉络膜参数的改变及其可能的临床应用价值，并探讨对这些患者影响较大的视觉功能障碍。
