Etminan Mahyar, Samii Ali, He Bonnie
Department of Ophthalmology and Visual Sciences, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Department of Neurology, University of Washington, Seattle, WA, USA.
J Curr Ophthalmol. 2018 Sep 5;30(4):365-367. doi: 10.1016/j.joco.2018.08.004. eCollection 2018 Dec.
To examine the risk of developing Parkinson's Disease (PD) in patients who are newly diagnosed with neovascular age-related macular degeneration (nAMD).
This was a cohort study using the British Columbia (BC) Retinal Disease Database. Data from 2009 to 2013 was accessed. Rates of PD in patients prior to the diagnosis of nAMD were computed and compared to the rates of patients newly diagnosed with PD after the diagnosis of nAMD.
The rate of PD prior to the diagnosis of nAMD was 1.42 per 100,000 person-years. The rate of PD after the diagnosis of nAMD was 2.88/100,000 person-years. The rate ratio was 2.03 (95% CI; 1.31-3.16).
The findings suggest that patients who are diagnosed with nAMD are at a significantly higher risk of developing PD later in life. More studies are needed to identify the pathological mechanism between the two diseases.
研究新诊断为新生血管性年龄相关性黄斑变性（nAMD）的患者患帕金森病（PD）的风险。
这是一项使用不列颠哥伦比亚省（BC）视网膜疾病数据库的队列研究。获取了2009年至2013年的数据。计算了nAMD诊断前患者的PD发病率，并与nAMD诊断后新诊断为PD的患者发病率进行比较。
nAMD诊断前的PD发病率为每10万人年1.42例。nAMD诊断后的PD发病率为每10万人年2.88例。发病率比为2.03（95%CI；1.31 - 3.16）。
研究结果表明，被诊断为nAMD的患者在晚年患PD的风险显著更高。需要更多研究来确定这两种疾病之间的病理机制。
