Moschos Marilita M, Chatziralli Irini P
a Electrophysiology Laboratory, 1st Department of Ophthalmology , University of Athens , Athens , Greece.
Semin Ophthalmol. 2018;33(4):494-497. doi: 10.1080/08820538.2017.1307423. Epub 2017 Apr 10.
The purpose of this study was to evaluate retinal and choroidal thickness in patients with Parkinson's disease (PD) using spectral domain-optical coherence tomography (SD-OCT).
Participants in our study were 31 PD patients and 25 age-matched healthy controls. All participants underwent best-corrected visual acuity (BCVA) measurement, slit-lamp biomicroscopy, dilated fundoscopy, and SD-OCT. Macular and retinal nerve fiber layer (RNFL) thickness and choroidal thickness in all quadrants were recorded.
There was a statistically significant reduction in average, superior, and temporal RNFL thickness, average ganglion cell complex, and choroidal thickness in the subfoveal area and in all quadrants between patients with PD and controls.
The role of the choroidal vasculature in the pathophysiology of PD should be further scrutinized.
本研究旨在使用频域光学相干断层扫描（SD - OCT）评估帕金森病（PD）患者的视网膜和脉络膜厚度。
我们研究的参与者为31例PD患者和25例年龄匹配的健康对照者。所有参与者均接受了最佳矫正视力（BCVA）测量、裂隙灯生物显微镜检查、散瞳眼底镜检查和SD - OCT检查。记录了黄斑、视网膜神经纤维层（RNFL）厚度以及所有象限的脉络膜厚度。
PD患者与对照组相比，平均、上方和颞侧RNFL厚度、平均神经节细胞复合体厚度以及黄斑下区域和所有象限的脉络膜厚度均有统计学意义的降低。
脉络膜血管系统在PD病理生理学中的作用应进一步研究。
