Competence Cluster of Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Leipzig, Germany; Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany; V(th) Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
V(th) Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
J Clin Lipidol. 2018 Mar-Apr;12(2):455-463.e3. doi: 10.1016/j.jacl.2018.01.007. Epub 2018 Jan 31.
Saturated fatty acids are thought to be harmful by increasing the risk for cardiovascular events.
We examined the associations of erythrocyte saturated fatty acids with total and cardiovascular mortality in patients referred for coronary angiography.
Red blood cell saturated fatty acid (RBC SFA) proportions were measured by gas chromatography at baseline in 3259 participants of the Ludwigshafen Risk and Cardiovascular Health study. Associations of saturated fatty acid concentrations with mortality were investigated using Cox proportional hazards regression.
During a median follow-up of 9.9 years, 975 patients (29.9%) died and 614 patients (18.8%) died of cardiovascular causes. The proportion of palmitic acid (PA, C16:0) ranged from 15.1% to 27.4% with a mean (standard deviation) of 21.9% (1.15%) and was associated with an increased risk for mortality in models adjusted for conventional cardiovascular risk factors. An increase of 1-standard deviation in PA was associated with a hazard ratio (95% confidence interval) of 1.08 (1.01-1.16) for all cause and 1.05 (0.96-1.15) for cardiovascular mortality after adjustment for cardiovascular risk factors. For the other investigated RBC SFA (C14:0, C18:0, C20:0, C22:0, and C24:0), there was no association with mortality and also not for the sum of all saturated fatty acids.
Our results reveal association with increased mortality risk only for PA but not for the other RBC SFAs or the sum of all RBC SFAs and emphasize the need to investigate each fatty acid individually rather than studying groups of fatty acids.
人们认为饱和脂肪酸会增加心血管事件的风险，因此对其有害。
我们研究了红细胞饱和脂肪酸（erythrocyte saturated fatty acids，RBC SFA）与接受冠状动脉造影检查的患者的总死亡率和心血管死亡率之间的关系。
在路德维希港风险与心血管健康研究（Ludwigshafen Risk and Cardiovascular Health study）的 3259 名参与者中，基线时通过气相色谱法测量红细胞饱和脂肪酸（RBC SFA）的比例。使用 Cox 比例风险回归分析来研究饱和脂肪酸浓度与死亡率之间的关系。
在中位数为 9.9 年的随访期间，975 名患者（29.9%）死亡，614 名患者（18.8%）死于心血管原因。棕榈酸（palmitic acid，PA，C16:0）的比例范围为 15.1%-27.4%，平均值（标准差）为 21.9%（1.15%），与校正传统心血管危险因素后的死亡率增加相关。PA 每增加 1 个标准差，全因死亡率的风险比（95%置信区间）为 1.08（1.01-1.16），心血管死亡率的风险比（95%置信区间）为 1.05（0.96-1.15）。对于其他研究的 RBC SFA（C14:0、C18:0、C20:0、C22:0 和 C24:0），与死亡率之间没有关联，对于所有饱和脂肪酸总和也是如此。
我们的研究结果仅显示 PA 与死亡率增加风险相关，而与其他 RBC SFA 或所有 RBC SFA 总和无关，这强调了需要单独研究每种脂肪酸，而不是研究脂肪酸组。
