Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; These authors contributed equally to this work.
West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; These authors contributed equally to this work.
Trends Endocrinol Metab. 2018 Jun;29(6):361-363. doi: 10.1016/j.tem.2018.02.004. Epub 2018 Feb 14.
The genetic etiology for obesity-related traits remains elusive. Recent studies link novel ADCY3 variants to obesity and diabetes, and identify an important role of ADCY3-mediated signaling at neuronal primary cilia in the predisposition of obesity. These findings provide new information on obesity etiology and suggest potential anti-obesity therapeutic strategies.
肥胖相关特征的遗传病因仍然难以捉摸。最近的研究将新型 ADCY3 变体与肥胖和糖尿病联系起来，并确定了 ADCY3 介导的信号在肥胖易感性中神经元初级纤毛的重要作用。这些发现为肥胖病因提供了新信息，并提示了潜在的抗肥胖治疗策略。
