UPMC-Presbyterian Hospital, Department of Anaesthesiology, University of Pittsburgh Medical Center, C-Wing, Suite 200, 200, Lothrop St., Pittsburgh, PA 15213 USA.
UPMC-Presbyterian Hospital, Department of Anaesthesiology, University of Pittsburgh Medical Center, C-Wing, Suite 200, 200, Lothrop St., Pittsburgh, PA 15213 USA.
Anaesth Crit Care Pain Med. 2018 Dec;37(6):571-575. doi: 10.1016/j.accpm.2018.02.002. Epub 2018 Feb 15.
The purpose of this retrospective case-control study was to investigate preoperative risk factors for unexpected postoperative intensive care unit (ICU) admissions in patients undergoing non-emergent surgical procedures in a tertiary medical centre.
A medical record review of adult patients undergoing elective non-cardiac and non-transplant major surgical procedures during the period of January 2011 through December 2015 in the operating rooms of a large university hospital was carried out. The primary outcome assessed was unexpected ICU admission, with mortality as a secondary outcome. Demographic data, length of hospital and ICU stay and preoperative comorbidities were also obtained as exposure variables. Propensity score matching was then employed to yield a study and control group.
The group of patients who met inclusion criteria in the study and the control group that did not require ICU admission were obtained, each containing 1191 patients after propensity matching. Patients with acute and/or chronic kidney injury (odds ratio (OR) 2.20 [1.75-2.76]), valvular heart disease (OR: 1.94 [1.33-2.85]), peripheral vascular disease (PVD) (OR: 1.41 [1.02-1.94]) and congestive heart failure (CHF) (OR: 1.80 [1.31-2.46]) were all associated with increased unexpected ICU admission. History of cerebrovascular accident (CVA) (OR: 3.03 [1.31-7.01]) and acute and/or chronic kidney injury (OR: 1.62 [1.12-2.35]) were associated with increased mortality in all patients; CVA was also associated with increased mortality (OR: 3.15 [1.21-8.20]) specifically in the ICU population.
CHF, acute/chronic kidney injury, PVD and valve disease were significantly associated with increased unexpected ICU admission; patients with CVA suffered increased mortality when admitted to the ICU.
本回顾性病例对照研究的目的是探讨在一家三级医疗中心进行非紧急手术的患者中,术后意外入住重症监护病房(ICU)的术前危险因素。
对 2011 年 1 月至 2015 年 12 月期间在一家大型大学医院手术室接受择期非心脏和非移植大手术的成年患者的病历进行了回顾性审查。主要评估结果是意外 ICU 入住,次要评估结果是死亡率。还获得了人口统计学数据、住院和 ICU 停留时间以及术前合并症等暴露变量。然后进行倾向评分匹配,得出研究组和对照组。
在研究组和未入住 ICU 的对照组中获得了符合纳入标准的患者,每组在倾向评分匹配后各有 1191 例患者。急性和/或慢性肾损伤(比值比(OR)2.20[1.75-2.76])、瓣膜性心脏病(OR:1.94[1.33-2.85])、外周血管疾病(PVD)(OR:1.41[1.02-1.94])和充血性心力衰竭(CHF)(OR:1.80[1.31-2.46])均与意外 ICU 入住增加相关。既往有脑血管意外(CVA)(OR:3.03[1.31-7.01])和急性和/或慢性肾损伤(OR:1.62[1.12-2.35])的患者在所有患者中均与死亡率增加相关;CVA 也与 ICU 人群的死亡率增加相关(OR:3.15[1.21-8.20])。
CHF、急性/慢性肾损伤、PVD 和瓣膜病与意外 ICU 入住增加显著相关;CVA 患者入住 ICU 时死亡率增加。