Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, P O Box 1495, Spokane, WA 99210-1495, USA.
Department of Geography, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6.
Mult Scler Relat Disord. 2018 Apr;21:30-34. doi: 10.1016/j.msard.2018.02.005. Epub 2018 Feb 6.
Studies have indicated an association between low Ultraviolet B (UVB) exposure and an increased risk of developing multiple sclerosis (MS). Few studies, however, have explored whether UVB exposure is associated with the age at MS symptom onset.
We investigated the potential association between cumulative early life ambient UVB exposure and age at MS onset, using satellite data to measure ambient UVB exposure.
Adult onset MS patients were selected from the University of British Columbia's MS genetic database (1980-2005). Patients' places of residence from birth to age 18 years were geocoded (latitude and longitude) and assigned UVB values using NASA's Total Ozone Mapping Spectrometer (TOMS) dataset. Linear regression was used to explore the relationship between cumulative UVB exposure (measured for age periods 0-6, 7-12, 13-18, 0-12, and 0-18) and age at MS onset.
3226 patients were included in the analysis. Of these, 74% were female, with an overall mean symptom onset age of 33.3 years. At onset, a total of 2944 (91%) had a relapsing-remitting disease course, 254 (8%) had primary progressive and the disease course for 28 (1%) was unknown. No significant associations between cumulative early life ambient UVB exposure and age at MS onset were observed. Patient sex, MS phenotype, and immigration to Canada after age 18 were significantly associated with age of onset (p < 0.01).
Early life ambient UVB, as measured by satellite imagery, was not significantly associated with the age at MS onset.
研究表明，低紫外线 B（UVB）暴露与多发性硬化症（MS）发病风险增加之间存在关联。然而，很少有研究探讨 UVB 暴露是否与 MS 发病年龄有关。
我们使用卫星数据测量环境 UVB 暴露，研究了早期生活环境 UVB 暴露与 MS 发病年龄之间的潜在关联。
从不列颠哥伦比亚大学的 MS 遗传数据库（1980-2005 年）中选择成年发病的 MS 患者。将患者从出生到 18 岁的居住地进行地理编码（纬度和经度），并使用美国宇航局的总臭氧绘图光谱仪（TOMS）数据集分配 UVB 值。使用线性回归探索累积 UVB 暴露（针对 0-6 岁、7-12 岁、13-18 岁、0-12 岁和 0-18 岁的年龄期进行测量）与 MS 发病年龄之间的关系。
共纳入 3226 例患者。其中，74%为女性，总体平均发病年龄为 33.3 岁。发病时，2944 例（91%）为复发缓解型病程，254 例（8%）为原发性进展型，28 例（1%）病程不明。早期生活环境 UVB 暴露与 MS 发病年龄之间未观察到显著关联。患者性别、MS 表型和 18 岁后移民加拿大与发病年龄显著相关（p < 0.01）。
卫星图像测量的早期生活环境 UVB 与 MS 发病年龄无显著相关性。
