Center of Molecular Medicine, Karolinska University Hospital, Solna, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.
Sci Rep. 2021 Oct 25;11(1):20989. doi: 10.1038/s41598-021-00344-0.
Vitamin D deficiency is associated with an increased risk of multiple sclerosis (MS). However, its effect on the age of disease onset remains unclear. This study examines the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and age of first symptom onset among recently diagnosed MS patients. Serum 25(OH)D was measured from forty MS patients sampled near disease onset. After correcting seasonal variability, the association between 25(OH)D levels, along with other clinical measures such as IgG index, and age at MS onset was examined using multivariable linear regression. Serum 25(OH)D was not correlated with age at onset (P > 0.5). We observed bias among previously reported associations between 25(OH)D and MS disease measures resulting from non-random distribution of sampling by season. After correcting for seasonal 25(OH)D and other clinical measures, only CSF IgG index remained significantly associated with age at disease onset (β = - 5.35, P = 0.028). In summary, we observed no association between age at onset and serum 25(OH)D levels but observed a negative correlation with CSF IgG index, although this will require further investigation.
维生素 D 缺乏与多发性硬化症（MS）的风险增加有关。然而，其对疾病发病年龄的影响尚不清楚。本研究检查了血清 25-羟维生素 D（25（OH）D）水平与近期诊断为 MS 的患者首发症状年龄之间的关系。从 40 名 MS 患者在疾病发作附近采集的血清中测量了 25（OH）D。在纠正季节性可变性后，使用多变量线性回归检查了 25（OH）D 水平以及 IgG 指数等其他临床指标与 MS 发病年龄之间的关联。血清 25（OH）D 与发病年龄无相关性（P>0.5）。我们观察到，由于 25（OH）D 和 MS 疾病指标之间的关联在采样季节上存在非随机分布，导致之前报道的这些关联存在偏差。在纠正了季节性 25（OH）D 和其他临床指标后，只有 CSF IgG 指数与疾病发病年龄仍显著相关（β= -5.35，P=0.028）。总之，我们观察到发病年龄与血清 25（OH）D 水平之间无关联，但与 CSF IgG 指数呈负相关，尽管这需要进一步研究。
