Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran; Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Mult Scler Relat Disord. 2018 Apr;21:46-50. doi: 10.1016/j.msard.2018.01.020. Epub 2018 Feb 2.
Menstruation is suggested to affect multiple sclerosis (MS) symptoms, while the effect of MS on menstruation is not studied before. Here, we aimed to compare the pattern of menstrual cycle and its symptoms between MS patients and healthy controls.
This is a cross-sectional study conducted during 2015-2016 in MS clinic of Kashani hospital, Isfahan, Iran. We included female patients > 14 years with diagnosis of relapsing-remitting MS, and healthy subjects as the control group. We collected data regarding menarche age, menstrual characteristics, history of premenstrual syndrome, the amount of menstrual bleeding, and the possible perimenstrual symptoms from all subjects. Also, MS patients were asked to report changes in menstrual characteristics after MS occurrence.
The final study population contained 181 MS patients and 202 healthy subjects. The mean age in MS and control group were 36.04 ± 9.86 and 35.16 ± 11.30, respectively (P-value = 0.426). Menarche age in MS patients and control group were not statistically different (13.59 ± 1.87 and 13.29 ± 1.53, respectively; P-value = 0.087). Changing menstrual characteristics was reported in 70 MS patients (38.7%). Irregular menstrual cycle increased from 21% to 40.3% after occurrence of MS (P-value < 0.001) and was reported 24.7% in the control group. MS patients versus controls reported more symptoms before, during, and after their menstrual period (P-values < 0.001).
We found no difference regarding menstrual characteristics in MS patients before onset of the disease and healthy controls. Irregular menstrual cycle was observed more after the disease occurrence while other menstrual characteristics did not change. Moreover, MS patients reported many more perimenstrual symptoms.
月经被认为会影响多发性硬化症（MS）的症状，而 MS 对月经的影响之前尚未得到研究。在这里，我们旨在比较 MS 患者和健康对照组的月经周期模式及其症状。
这是一项横断面研究，于 2015 年至 2016 年在伊朗伊斯法罕 Kashani 医院的 MS 诊所进行。我们纳入了年龄> 14 岁、诊断为复发缓解型 MS 的女性患者，并将健康受试者作为对照组。我们从所有受试者中收集了初潮年龄、月经特征、经前期综合征病史、月经出血量以及可能的围经期症状等数据。此外，我们还询问了 MS 患者在 MS 发病后月经特征的变化情况。
最终的研究人群包括 181 名 MS 患者和 202 名健康受试者。MS 组和对照组的平均年龄分别为 36.04 ± 9.86 岁和 35.16 ± 11.30 岁（P 值=0.426）。MS 患者和对照组的初潮年龄无统计学差异（分别为 13.59 ± 1.87 岁和 13.29 ± 1.53 岁；P 值=0.087）。70 名 MS 患者（38.7%）报告了月经特征的变化。MS 发病后，月经周期不规则的比例从 21%增加到 40.3%（P 值<0.001），对照组为 24.7%。MS 患者在月经前、期间和后报告的症状比对照组更多（P 值均<0.001）。
我们发现 MS 患者在发病前与健康对照组的月经特征无差异。发病后月经周期不规则更为常见，而其他月经特征无变化。此外，MS 患者报告了更多的围经期症状。
