我们能从多发性硬化症的性别差异中学到什么？
What Can We Learn from Sex Differences in MS?
作者信息
Coyle Patricia K
机构信息
Department of Neurology, Stony Brook University, Stony Brook, NY 11794, USA.
出版信息
J Pers Med. 2021 Oct 7;11(10):1006. doi: 10.3390/jpm11101006.
Abstract
Multiple sclerosis (MS) is the major acquired central nervous system disease of young adults. It is a female predominant disease. Multiple aspects of MS are influenced by sex-based differences. This has become an important area of research and study. It teaches us how the impact of sex on a disease can lead to new insights, guidelines, management, and treatments.
摘要
多发性硬化症（MS）是青壮年主要的后天性中枢神经系统疾病。它是一种女性主导的疾病。MS的多个方面受到基于性别的差异影响。这已成为一个重要的研究领域。它让我们了解性别对疾病的影响如何能带来新的见解、指导方针、管理方法和治疗手段。
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Mult Scler Relat Disord. 2022 Jan;57:103347. doi: 10.1016/j.msard.2021.103347. Epub 2021 Oct 28.
2
Pregnancy in multiple sclerosis women with relapses in the year before conception increases the risk of long-term disability worsening.怀孕前一年病情复发的多发性硬化症女性怀孕会增加长期残疾恶化的风险。
Mult Scler. 2022 Mar;28(3):472-479. doi: 10.1177/13524585211023365. Epub 2021 Jun 16.
3
Effects of the Menstrual Cycle on Neurological Disorders.月经周期对神经紊乱的影响。
Curr Neurol Neurosci Rep. 2021 May 10;21(7):34. doi: 10.1007/s11910-021-01115-0.
4
Effects of Menopause in Women With Multiple Sclerosis: An Evidence-Based Review.绝经对多发性硬化症女性的影响：一项基于证据的综述。
Front Neurol. 2021 Mar 19;12:554375. doi: 10.3389/fneur.2021.554375. eCollection 2021.
5
The nature of genetic and environmental susceptibility to multiple sclerosis.多发性硬化症的遗传和环境易感性的本质。
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7
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