Department of Rehabilitation, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, Victoria, 3065, Australia.
Statistics and Decision Analysis Academic Platform, Melbourne Brain Centre, The Florey Institute of Neuroscience and Mental Health, 245 Burgundy St, Heidelberg, Victoria, 3084, Australia.
Osteoporos Int. 2018 Apr;29(4):805-812. doi: 10.1007/s00198-018-4381-4. Epub 2018 Feb 18.
Sarcopenia is associated with poor function and increased risk of falls and disability. This work reports a systematic review and meta-analysis of prevalence of sarcopenia in post acute inpatient rehabilitation. Sarcopenia is found to be present in approximately 50% of rehabilitation patients and its prevalence may vary with admission diagnosis.
To conduct a systematic review and meta-analysis of reported prevalence of sarcopenia in post acute inpatient rehabilitation.
Systematic review conducted according to PRISMA guidelines (PROSPERO registration number CRD42016054135). Databases searched MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Methodology Register, and CINAHL. Studies considered the following: published January 1988-February 2017. Key terms are as follows: "sarcopenia" AND "inpatient rehabilitation" OR "rehabilitation" AND/OR "prevalence". Abstracts and subsequently full studies reporting sarcopenia prevalence in adults admitted to rehabilitation reviewed irrespective of design, provided sarcopenia diagnosis included at least assessment of muscle mass. Random effect meta-analysis was conducted. Methodological quality assessment: Agency for Healthcare Research and Quality, US Department of Health and Human Services tool (MORE tool); Joanna Briggs Institute Prevalence Critical Appraisal Tool.
Four hundred twenty-six studies identified during initial search, 399 excluded after reviewing titles and abstracts, 21 full text articles reviewed, and six studies met inclusion criteria. Patient populations: after hip fracture (five studies), general deconditioning (one study). Identified sarcopenia prevalence ranged from 0.28 to 0.69. Pooled sarcopenia prevalence obtained with random effect meta-analysis: 0.56 (95% CI 0.46-0.65), heterogeneity I2 = 92.9%. Main quality shortcomings: lack of reporting of inter- and intra-rater reliability, lack of generalizability to other rehabilitation populations.
Original research examining sarcopenia prevalence in inpatient rehabilitation is scarce. Patient populations studied to date are not representative of general rehabilitation population with regard to both age and admission diagnoses. Sarcopenia may be present in approximately half of rehabilitation patients and its prevalence may vary with admission diagnosis.
对急性住院康复后肌少症的报告患病率进行系统评价和荟萃分析。
根据 PRISMA 指南进行系统评价（PROSPERO 注册号 CRD42016054135）。检索 MEDLINE、EMBASE、Cochrane 系统评价数据库、Cochrane 对照试验中心注册库（CENTRAL）、Cochrane 方法学登记册和 CINAHL。研究考虑了以下内容：1988 年 1 月至 2017 年 2 月发表的研究。关键词如下：“肌少症”和“住院康复”或“康复”和/或“患病率”。综述和随后报告了接受康复治疗的成年人肌少症患病率的所有研究，无论设计如何，只要肌少症诊断包括肌肉量评估，都进行了回顾。进行了随机效应荟萃分析。方法学质量评估：美国卫生与公众服务部医疗保健研究与质量局工具（MORE 工具）；乔安娜·布里格斯研究所患病率关键评估工具。
初始搜索确定了 426 项研究，在审查标题和摘要后排除了 399 项，审查了 21 篇全文文章，符合纳入标准的 6 项研究。患者人群：髋关节骨折后（5 项研究），一般身体虚弱（1 项研究）。确定的肌少症患病率范围为 0.28 至 0.69。随机效应荟萃分析得出的肌少症总患病率为 0.56（95%CI 0.46-0.65），异质性 I2=92.9%。主要质量缺陷：缺乏报告观察者间和观察者内可靠性，缺乏对其他康复人群的普遍性。
关于急性住院康复中肌少症患病率的原始研究很少。迄今为止研究的患者人群在年龄和入院诊断方面都不能代表一般康复人群。肌少症可能存在于大约一半的康复患者中，其患病率可能因入院诊断而异。
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