Yoshimura Yoshihiro, Nagano Fumihiko, Matsumoto Ayaka, Shimazu Sayuri, Shiraishi Ai, Kido Yoshifumi, Bise Takahiro, Hamada Takenori, Yoneda Kouki
Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto 869-1106, Japan.
Nutrients. 2025 May 7;17(9):1599. doi: 10.3390/nu17091599.
: Sarcopenia and malnutrition are common in post-stroke patients, impairing recovery. Medium-chain triglycerides (MCT) may support muscle metabolism, while chair-stand exercises improve strength and mobility. However, their combined effects remain unclear. This study evaluated the synergistic effects of MCT supplementation and high-frequency chair-stand exercise on physical function and muscle health in post-stroke patients. : A retrospective cohort study included 1080 post-stroke patients categorized into three groups: (1) MCT supplementation alone, (2) chair-stand exercise alone, and (3) both combined. MCT supplementation consisted of ~40 g/day MCT oil or powder. Functional outcomes were assessed using the Functional Independence Measure (FIM-motor), while muscle health was evaluated by handgrip strength (HGS) and skeletal muscle index (SMI). Multiple linear regression analyses were performed, adjusting for confounders. : The combined intervention group showed significantly greater improvements in FIM-motor scores at discharge (B = 8.79, 95% CI: 5.64-11.95, β = 0.32, 0.001) and FIM-motor gain (B = 6.02, 95% CI: 3.42-8.62, β = 0.29, 0.001) compared to the control. Increases in HGS (B = 2.441, 95% CI: 0.483-4.398, β = 0.18, = 0.015) and SMI (B = 0.194, 95% CI: 0.102-0.419, β = 0.12, = 0.039) were also observed. Chair-stand exercise was performed a median of 62 times/day and independently improved outcomes, while MCT alone had limited effects. : MCT supplementation combined with chair-stand exercise enhances functional recovery and muscle health in post-stroke patients, supporting its role in rehabilitation. Further research is needed to evaluate long-term effects and to examine the pharmacokinetics of MCTs, including blood concentrations, in broader populations.
肌肉减少症和营养不良在中风后患者中很常见，会影响恢复。中链甘油三酯（MCT）可能有助于肌肉代谢，而坐立试验可提高力量和活动能力。然而，它们的联合效果尚不清楚。本研究评估了补充MCT和高频坐立试验对中风后患者身体功能和肌肉健康的协同作用。：一项回顾性队列研究纳入了1080例中风后患者，分为三组：（1）单独补充MCT；（2）单独进行坐立试验；（3）两者联合。补充MCT包括每天约40克MCT油或粉末。使用功能独立性测量（FIM-运动）评估功能结局，同时通过握力（HGS）和骨骼肌指数（SMI）评估肌肉健康。进行了多元线性回归分析，并对混杂因素进行了调整。：与对照组相比，联合干预组出院时FIM-运动评分（B = 8.79，95%CI：5.64-11.95，β = 0.32，P < 0.001）和FIM-运动增益（B = 6.02，95%CI：3.42-8.62，β = 0.29，P < 0.001）有显著更大的改善。还观察到HGS（B = 2.441，95%CI：0.483-4.398，β = 0.18，P = 0.015）和SMI（B = 0.194，95%CI：0.102-0.419，β = 0.12，P = 0.039）增加。坐立试验中位数为每天62次，可独立改善结局，而单独使用MCT效果有限。：补充MCT与坐立试验相结合可增强中风后患者的功能恢复和肌肉健康，支持其在康复中的作用。需要进一步研究以评估长期效果，并在更广泛人群中研究MCT的药代动力学，包括血药浓度。
