Ran Bing, Wei Jun
Department of Pain, the First Affiliated Hospital of Gannan Medical Unversity, Ganzhou 341000, Jiangxi, China.
Zhongguo Gu Shang. 2017 Sep 25;30(9):876-880. doi: 10.3969/j.issn.1003-0034.2017.09.019.
Tophi deposit in the peripheral bone joints or soft tissues are formed by uric acid and urate crystal. It does not only affect local appearance but also destroy the bone and joint structure, resulting in loss of function. Traditional medical treatment is an effective way to control the hyperuricemia, but it is ineffective to tophus. Surgery is a relatively effective method for the treatment of tophus. It can successfully reduces the content of uric acid in the body and improves the limbs function, but it causes surgical trauma and complications. As new medicine, Urcase is a hot spot in the present study. It can not only control the blood uric acid level but also dissolve part of tophus. But the cost is higher than traditional medicines. There is still dispute in treatment for advanced tophus.
痛风石沉积于外周骨关节或软组织，由尿酸和尿酸盐结晶形成。它不仅影响局部外观，还会破坏骨骼和关节结构，导致功能丧失。传统药物治疗是控制高尿酸血症的有效方法，但对痛风石无效。手术是治疗痛风石相对有效的方法。它能成功降低体内尿酸含量，改善肢体功能，但会造成手术创伤和并发症。作为新药，尿酸酶是目前研究的热点。它不仅能控制血尿酸水平，还能溶解部分痛风石。但其费用高于传统药物。对于晚期痛风石的治疗仍存在争议。
