Peterseim U, von Gizycki-Nienhaus B, Schattenkirchner M, Meurer M
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.
Hautarzt. 1994 Nov;45(11):799-802. doi: 10.1007/s001050050175.
The tophus is a characteristic and pathognomonic sign of chronic gout. Before effective drugs were available for the treatment of hyperuricaemia about 50-60% of patients with gout developed clinically and radiologically apparent urate crystal deposits. Clinical cutaneous manifestations of chronic gout are now rarely observed. However, the presence of degenerative tissues, as in idiopathic osteoarthritis of the fingers, may predispose to the deposition of urate crystals. We report on a patient with secondary--probably diuretic-induced--hyperuricaemia and gout tophiin Heberden's nodes.
痛风石是慢性痛风的特征性和诊断性标志。在有有效药物治疗高尿酸血症之前,约50-60%的痛风患者会出现临床和放射学上明显的尿酸盐晶体沉积。慢性痛风的临床皮肤表现现在很少见。然而,手指特发性骨关节炎等退行性组织的存在可能易导致尿酸盐晶体沉积。我们报告一例继发性(可能由利尿剂引起)高尿酸血症和痛风石累及赫伯登结节的患者。