子痫前期患者胎盘组织中的胎盘生长因子、血管内皮生长因子及缺氧诱导因子-1α
Placental growth factor, vascular endothelial growth factor, and hypoxia-inducible factor-1α in the placentas of women with pre-eclampsia.
作者信息
Ali Lobna E, Salih Magdi M, Elhassan Elhassan M, Mohmmed Ahmed A, Adam Ishag
机构信息
a Department of Histopathology and Cytology, Ahlia College of Medical Laboratory Sciences , Port Sudan , Sudan.
b Faculty of Medical Laboratory Sciences , University of Khartoum , Khartoum , Sudan.
出版信息
J Matern Fetal Neonatal Med. 2019 Aug;32(16):2628-2632. doi: 10.1080/14767058.2018.1443066. Epub 2018 Feb 28.
BACKGROUND
Although the exact mechanism of pre-eclampsia - high blood pressure and proteinuria after 20 gestational weeks - is not yet fully understood, placental growth factor (PLGF), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor (HIF) are known to play important roles in vascularization and in the pathology of pre-eclampsia.
METHODS
PLGF, VEGF, and HIF-1α were evaluated by immunohistochemistry in the placentas of Sudanese women with mild or severe pre-eclampsia, and in normal controls.
RESULTS
Sixty-two women had severe pre-eclampsia, 102 had mild pre-eclampsia and 101 women served as healthy controls. Immunohistochemical staining of PLGF was significantly lower in placentas of women with severe pre-eclampsia (16%) compared with those with mild pre-eclampsia (8.8%) and placentas of normotensive women (40.6%; p < .001). Significantly more of the pre-eclamptic placentas expressed VEGF: in 32%, 17.6%, and 14.9% (p = .020) of the placentas of women with severe or mild pre-eclampsia and in controls, respectively. Significantly more of the pre-eclamptic placentas expressed HIF-1α: in 15%, 10.8%, and 5.0% of the placentas of women with severe or mild pre-eclampsia, and in controls, respectively (p = .044).
CONCLUSION
The current study showed that PLGF, VEGF, and HIF-1α are involved in the pathophysiology of pre-eclampsia.
背景
尽管子痫前期（妊娠20周后出现高血压和蛋白尿）的确切机制尚未完全明确，但已知胎盘生长因子（PLGF）、血管内皮生长因子（VEGF）和缺氧诱导因子（HIF）在血管形成以及子痫前期的病理过程中发挥重要作用。
方法
通过免疫组织化学方法评估苏丹患有轻度或重度子痫前期的女性胎盘以及正常对照者胎盘中的PLGF、VEGF和HIF-1α。
结果
62名女性患有重度子痫前期，102名患有轻度子痫前期，101名女性作为健康对照。与轻度子痫前期女性（8.8%）和血压正常女性（40.6%）的胎盘相比，重度子痫前期女性胎盘的PLGF免疫组织化学染色显著降低（16%；p <.001）。子痫前期胎盘表达VEGF的比例显著更高：重度或轻度子痫前期女性胎盘以及对照者胎盘中分别为32%、17.6%和14.9%（p = 0.020）。子痫前期胎盘表达HIF-1α的比例显著更高：重度或轻度子痫前期女性胎盘以及对照者胎盘中分别为15%、10.8%和5.%;（p = 0.044）。
结论
当前研究表明，PLGF、VEGF和HIF-1α参与了子痫前期的病理生理过程。
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