H/K-ATPase Inhibition, Antiradical Effects of a Flavonoid-rich Fraction of , and PASS Prediction of its Isolated Compounds.

BACKGROUND

, commonly referred to as pink lady, has several medicinal uses including peptic ulcer. This study investigated the inhibitory effects of extract on H/K-ATPase and also assessed its antiradical activity. study of some isolated compounds of this plant was also carried out to affirm the suspected binding properties of extract to H/K-ATPase enzyme.

MATERIALS AND METHODS

whole plant extract was obtained after extraction process and then assessed for its ability to scavenge free radicals in four test models. Its ability to inhibit the activity of H/K-ATPase enzyme was also evaluated. Molecular docking was carried out on phytoconstituents, namely, vitexin, isovitexin, orientin, and isoorientin reported to be present in the whole plant extract.

RESULTS

Data obtained indicated that extract (DRE) exhibits strong antioxidant activity. DRE also showed inhibitory effects on H/K-ATPase enzyme activity. Docking studies affirmed the binding effect of the extract to H/K-ATPase.

CONCLUSION

These findings suggest that the plant extract possess antioxidant and antipeptic ulcer activity.