Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
J Clin Biochem Nutr. 2011 Mar;48(2):107-11. doi: 10.3164/jcbn.10-79. Epub 2011 Feb 26.
Non-steroidal anti-inflammatory drugs are the most commonly prescribed drugs for arthritis, inflammation, and cardiovascular protection. However, they cause gastrointestinal complications. The pathophysiology of these complications has mostly been ascribed to non-steroidal anti-inflammatory drugs' action on the cyclooxygenase inhibition and the subsequent prostaglandin deficiency. However, recent clinical demonstrated the prevalence of non-steroidal anti-inflammatory drugs-induced small intestinal mucosal injury is more often than previously expected. In this review, we discuss the defense mechanisms of stomach, and the pathophysiology of non-steroidal anti-inflammatory drugs-induced injury of stomach and small intestine, especially focused on non-steroidal anti-inflammatory drugs' action on mitochondria.
非甾体抗炎药是最常用于治疗关节炎、炎症和心血管保护的药物。然而，它们会引起胃肠道并发症。这些并发症的病理生理学主要归因于非甾体抗炎药对环氧化酶的抑制作用以及随后的前列腺素缺乏。然而，最近的临床研究表明，非甾体抗炎药引起的小肠黏膜损伤比以前预期的更为常见。在这篇综述中，我们讨论了胃的防御机制，以及非甾体抗炎药引起的胃和小肠损伤的病理生理学，特别是重点讨论了非甾体抗炎药对线粒体的作用。
