粒细胞集落刺激因子在人类生殖中的作用。
Role of granulocyte colony-stimulating factor in human reproduction.
作者信息
Eftekhar Maryam, Naghshineh Elham, Khani Parisa
机构信息
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2018 Jan 29;23:7. doi: 10.4103/jrms.JRMS_628_17. eCollection 2018.
Abstract
As new research reveals, granulocyte colony-stimulating factor (G-CSF) plays an effective role in pregnancy success, considering that it not only affects the embryo implantation and ovarian function but also it promotes endometrial thickening and improves the pathophysiology of endometriosis, which all fundamentally lead to reducing pregnancy loss. In this review, we focus on the role of G-CSF in human reproduction. We summarized its role in ovulation, luteinized unruptured follicle syndrome, poor responders, improving repeated fertilization failure, endometrial receptivity and treatment of thin endometrium, and recurrent spontaneous abortion.
摘要
新的研究表明，粒细胞集落刺激因子（G-CSF）在妊娠成功方面发挥着有效作用，因为它不仅影响胚胎着床和卵巢功能，还能促进子宫内膜增厚并改善子宫内膜异位症的病理生理，所有这些从根本上都有助于减少妊娠丢失。在本综述中，我们聚焦于G-CSF在人类生殖中的作用。我们总结了其在排卵、未破裂卵泡黄素化综合征、低反应者、改善反复受精失败、子宫内膜容受性及薄型子宫内膜治疗以及复发性自然流产中的作用。
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