粒细胞集落刺激因子与生殖医学：综述
Granulocyte colony-stimulating factor and reproductive medicine: A review.
作者信息
Cavalcante Marcelo Borges, Costa Fabrício DA Silva, Barini Ricardo, Araujo Júnior E
机构信息
Department of Gynecology and Obstetrics, University of Fortaleza, Fortaleza-CE, Brazil.
Department of Perinatal Medicine, Pregnancy Research Centre, University of Melbourne, The Royal Women's Hospital, Melbourne, Victoria, Australia. ; Department of Obstetrics and Gynaecology, Pregnancy Research Centre, University of Melbourne, The Royal Women's Hospital, Melbourne, Victoria, Australia.
出版信息
Iran J Reprod Med. 2015 Apr;13(4):195-202.
BACKGROUND
Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes in reproductive medicine.
OBJECTIVE
A systematic review of the current use of G-CSF in patients who have difficulty conceiving and maintaining pregnancy was performed.
MATERIALS AND METHODS
Two electronic databases (PubMed/ Medline and Scopus) were searched. Study selection, data extraction and quality assessment were performed in duplicate. The subject codes used were granulocyte colony-stimulating factor, G-CSF, recurrent miscarriage, IVF failure, and endometrium.
RESULTS
The search of electronic databases resulted in 215 citations (PubMed/ Medline: 139 and Scopus: 76), of which 38 were present in both databases. Of the remaining 177 publications, seven studies were included in the present review.
CONCLUSION
Treatment with G-CSF is a novel proposal for immune therapy in patients with recurrent miscarriage and implantation failure following cycles of IVF. However, a larger number of well-designed studies are required for this treatment to be established.
背景
最近，有人提出使用粒细胞集落刺激因子（G-CSF）来改善生殖医学中的妊娠结局。
目的
对目前G-CSF在受孕和维持妊娠困难的患者中的应用进行系统评价。
材料与方法
检索了两个电子数据库（PubMed/Medline和Scopus）。研究选择、数据提取和质量评估均进行了两次。使用的主题代码为粒细胞集落刺激因子、G-CSF、复发性流产、体外受精失败和子宫内膜。
结果
电子数据库检索得到215条引文（PubMed/Medline：139条，Scopus：76条），其中38条在两个数据库中均有。在其余177篇出版物中，本综述纳入了7项研究。
结论
G-CSF治疗是复发性流产和体外受精周期后植入失败患者免疫治疗的新方案。然而，需要更多设计良好的研究来确立这种治疗方法。
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