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辅助性T细胞17/调节性T细胞失衡对艾滋病合并结核病患者HIV复制的影响

Effects of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis.

作者信息

Li Yanshuang, Sun Weijia

机构信息

Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

出版信息

Exp Ther Med. 2018 Mar;15(3):2879-2883. doi: 10.3892/etm.2018.5768. Epub 2018 Jan 18.

DOI:10.3892/etm.2018.5768
PMID:29456692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5795545/
Abstract

The purpose of this study was to determine the effect of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis (TB). We selected 32 patients with AIDS combined with TB infection in our hospital and 30 healthy individual as controls. The Th17/Treg ratio in peripheral blood lymphocytes was detected by flow cytometry. Compared with healthy subjects, Th17 cells first declined in HIV patients with TB, but gradually increased over the course of the disease. Treg showed an increasing trend in HIV patients with TB. The Th17/Treg ratio was significantly altered as the condition gradually deteriorated. ELISA showed that interleukin (IL)-17, IL-6 and IL-10 in patients with HIV complicated with TB were significantly lower than in healthy subjects. The imbalance of Th17/Treg cells can promote HIV virus replication in AIDS patients with TB infection, which can aggravate the condition.

摘要

本研究旨在确定辅助性T细胞17（Th17）/调节性T细胞（Treg）失衡对艾滋病合并结核病（TB）患者体内HIV复制的影响。我们选取了我院32例艾滋病合并结核感染患者，并选取30名健康个体作为对照。采用流式细胞术检测外周血淋巴细胞中Th17/Treg比值。与健康受试者相比，合并TB的HIV患者中Th17细胞最初下降，但在疾病过程中逐渐增加。Treg在合并TB的HIV患者中呈上升趋势。随着病情逐渐恶化，Th17/Treg比值发生显著变化。酶联免疫吸附测定（ELISA）显示，合并TB的HIV患者白细胞介素（IL）-17、IL-6和IL-10显著低于健康受试者。Th17/Treg细胞失衡可促进合并TB感染的艾滋病患者体内HIV病毒复制，从而加重病情。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/ea6e5109d6e4/etm-15-03-2879-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/34a9c59ebda1/etm-15-03-2879-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/2c4f7594ea40/etm-15-03-2879-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/94945ed42a63/etm-15-03-2879-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/c0adfbd3c773/etm-15-03-2879-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/e69e5b4162b4/etm-15-03-2879-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/ea6e5109d6e4/etm-15-03-2879-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/34a9c59ebda1/etm-15-03-2879-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/2c4f7594ea40/etm-15-03-2879-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/94945ed42a63/etm-15-03-2879-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/c0adfbd3c773/etm-15-03-2879-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/e69e5b4162b4/etm-15-03-2879-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b9/5795545/ea6e5109d6e4/etm-15-03-2879-g05.jpg

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