School of Clinical Medicine, Weifang Medical University, Weifang 261053, China.
Department of Medical Microbiology, Weifang Medical University, Weifang 261053, China.
Int J Mol Sci. 2019 Jan 15;20(2):340. doi: 10.3390/ijms20020340.
Epidemiological data from the Center of Disease Control (CDC) and the World Health Organization (WHO) statistics in 2017 show that 10.0 million people around the world became sick with tuberculosis. (MTB) is an intracellular parasite that mainly attacks macrophages and inhibits their apoptosis. It can become a long-term infection in humans, causing a series of pathological changes and clinical manifestations. In this review, we summarize innate immunity including the inhibition of antioxidants, the maturation and acidification of phagolysosomes and especially the apoptosis and autophagy of macrophages. Besides, we also elaborate on the adaptive immune response and the formation of granulomas. A thorough understanding of these escape mechanisms is of major importance for the prevention, diagnosis and treatment of tuberculosis.
2017 年，疾病控制与预防中心（CDC）和世界卫生组织（WHO）的流行病学数据显示，全球有 1000 万人感染结核病（MTB）。MTB 是一种细胞内寄生虫，主要攻击巨噬细胞并抑制其凋亡。它可以在人类中成为长期感染，导致一系列病理变化和临床表现。在这篇综述中，我们总结了先天免疫，包括抗氧化剂的抑制、吞噬体的成熟和酸化，特别是巨噬细胞的凋亡和自噬。此外，我们还详细阐述了适应性免疫反应和肉芽肿的形成。深入了解这些逃逸机制对于结核病的预防、诊断和治疗具有重要意义。
