Kawahara Naoki, Yamada Yuki, Ito Fuminori, Hojo Wataru, Iwabuchi Takuya, Kobayashi Hiroshi
Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Department of Research and Development, Cellspect Co., Ltd., Morioka, Iwate 020-0857, Japan.
Exp Ther Med. 2018 Mar;15(3):3000-3005. doi: 10.3892/etm.2018.5779. Epub 2018 Jan 19.
The aim of the present single-center retrospective study was to investigate the discrimination of malignant transformation from ovarian endometrioma (OE) using a near-infrared approach . Cystic fluid samples were collected from patients with OE (n=34) and endometriosis-associated ovarian cancer (EAOC) (n=12). The light reflected from each sample of cystic fluid [change in luminance, Δl (cd/m) = background luminance-cystic fluid luminance at 800 nm] was spectrally measured by a near-infrared CCD camera with band-path filter (800 nm). The Δl in EAOC was significantly lower compared with that in OE. On regression analysis, a positive correlation was observed between the Δl and Hb level in the cystic fluid, and this association was exponential. The diagnostic sensitivity and specificity of Δl was 83.3 and 94.1% at the cutoff value of 21.5 cd/m, with an area under the ROC curve of 0.897. The present study potentially provides a powerful near-infrared approach for quantitative discrimination between EAOC and benign OE, with high sensitivity and specificity, which may have clinical applications.
本单中心回顾性研究的目的是使用近红外方法研究卵巢子宫内膜异位囊肿（OE）恶变的鉴别诊断。收集了OE患者（n = 34）和子宫内膜异位症相关卵巢癌（EAOC）患者（n = 12）的囊液样本。用带通滤波器（800 nm）的近红外电荷耦合器件相机对每个囊液样本反射的光[亮度变化，Δl（cd/m）=背景亮度 - 800 nm处囊液亮度]进行光谱测量。EAOC中的Δl显著低于OE中的Δl。回归分析显示，囊液中的Δl与血红蛋白（Hb）水平呈正相关，且这种关联呈指数关系。在截断值为21.5 cd/m时，Δl的诊断敏感性和特异性分别为83.3%和94.1%，ROC曲线下面积为0.897。本研究可能为EAOC与良性OE之间的定量鉴别提供一种强大的近红外方法，具有高敏感性和特异性，可能具有临床应用价值。
