Ding Ning, Zhou Ning, Li Qinglin, Ren Guangming, Zhou Min
Department of Respiratory Medicine, The Affiliated Xuzhou City Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.
Oncol Lett. 2018 Mar;15(3):3662-3668. doi: 10.3892/ol.2018.7789. Epub 2018 Jan 12.
We investigated the short- and long-term efficacy of thoracoscope-assisted segmental resection of lung of non-small cell lung cancer (NSCLC). We selected a total of 94 patients with lung cancer in the early stage who were admitted to The First People's Hospital of Xuzhou for treatment between March 2011 and February 2012. Patients were divided randomly into either the control group (n=47) or the observation group (n=47). In the observation group, patients received thoracoscope-assisted segmental resection of lung, while in the control group, the conventional thoracic surgery was performed for treatment. After surgeries, we observed the incidence rate of complications among the two groups, and enzyme-linked immunosorbent assay (ELISA) was adopted to detect levels of inflammatory factors. We also compared the cardiac and pulmonary functions, the levels of immunoglobulins and subgroups of T lymphocytes in the peripheral blood of the patients. In addition, all patients attended a 5-year follow-up to determine the recurrence and survival rate. Compared to the control group, patients in the observation group had significantly less intra-operative bleeding volume, a shorter duration of surgery, and suffered slighter pain after surgery (P<0.05). After surgery, the incidence rate of complications in the observation group was significantly lower than that in the control group (P<0.05). After surgeries, patients in both groups experienced a remarkable improvement in cardiac and pulmonary functions, and the improvement in the observation group was superior to that of the control group (P<0.05). During the 5-year follow-up, the survival rate of the observation group is significantly higher than that in thecontrol group, and patients in the observation group experienced a lower recurrence rate than those in the control group (P<0.05). Thus, thoracoscope-assisted segmental resection of lung is of great significance in clinical practice.
我们研究了胸腔镜辅助下非小细胞肺癌（NSCLC）肺段切除术的短期和长期疗效。我们选取了2011年3月至2012年2月期间在徐州市第一人民医院接受治疗的94例早期肺癌患者。将患者随机分为对照组（n = 47）和观察组（n = 47）。观察组患者接受胸腔镜辅助下肺段切除术，而对照组则采用传统开胸手术治疗。手术后，我们观察两组并发症的发生率，并采用酶联免疫吸附测定（ELISA）检测炎症因子水平。我们还比较了患者的心肺功能、外周血免疫球蛋白水平和T淋巴细胞亚群。此外，所有患者均进行了5年随访，以确定复发率和生存率。与对照组相比，观察组患者术中出血量明显减少，手术时间缩短，术后疼痛较轻（P < 0.05）。术后，观察组并发症发生率明显低于对照组（P < 0.05）。手术后，两组患者的心肺功能均有显著改善，且观察组的改善程度优于对照组（P < 0.05）。在5年随访期间，观察组的生存率明显高于对照组，且观察组患者的复发率低于对照组（P < 0.05）。因此，胸腔镜辅助下肺段切除术在临床实践中具有重要意义。
