Pawlewicz Konrad, Szutkowski Zbigniew, Kawecki Andrzej
Department of Radiotherapy, The Maria Skłodowska Curie Memorial Cancer Centre and Institute of Oncology, Warsaw 02-781, Poland.
Oncol Lett. 2018 Mar;15(3):3890-3894. doi: 10.3892/ol.2018.7780. Epub 2018 Jan 12.
Adenoid cystic carcinoma (ACC) of the trachea is a relatively rare tumor among thoracic diseases. The present study reports the case of a 23-year-old woman with ACC of the trachea who underwent surgical resection of the tumor in The National Institute of Tuberculosis and Lung Diseases (Warsaw, Poland). Histopathological examination revealed that the tumor was not completely resected (R2 resection) and strict observation of the patient was therefore prescribed. After ~9 years of follow-up, clinical and histopathological tumor progression was confirmed and the patient was referred to the Centre of Oncology in Warsaw. The localization and advanced nature of the disease precluded surgical intervention, and radical radiotherapy was therefore performed using intensity-modulated radiation therapy. A total dose of 7,590 Gy, the planning target volume, was administered. A hyperfractionation scheme of radiotherapy was used: 2 fractions of 1.15 Gy daily, with at least a 6 h break in between. Tumor regression was observed following treatment and has been maintained for >3 years, assessed by clinical and computed tomography and positron emission tomography imaging examinations.
气管腺样囊性癌（ACC）是胸部疾病中一种相对罕见的肿瘤。本研究报告了一名23岁患有气管腺样囊性癌的女性病例，该患者在波兰华沙国家结核病和肺部疾病研究所接受了肿瘤手术切除。组织病理学检查显示肿瘤未完全切除（R2切除），因此对患者进行严密观察。经过约9年的随访，证实了肿瘤的临床和组织病理学进展，该患者被转诊至华沙肿瘤中心。疾病的定位和进展情况使得无法进行手术干预，因此采用调强放射治疗进行根治性放疗。给予计划靶体积的总剂量为7590 Gy。采用超分割放疗方案：每天2次，每次1.15 Gy，中间至少间隔6小时。治疗后观察到肿瘤消退，并通过临床、计算机断层扫描和正电子发射断层扫描成像检查评估，这种消退情况已维持超过3年。
