Honings Jimmie, Gaissert Henning A, van der Heijden Henricus F M, Verhagen Ad F T M, Kaanders Johannes H A M, Marres Henri A M
Department of Oto-Rhino-Laryngology and Head & Neck Surgery, Radboud University Nijmegen Medical Centre, the Netherlands.
Acta Otolaryngol. 2010 Jul;130(7):763-72. doi: 10.3109/00016480903403005.
Selecting patients that are candidates for surgical treatment is important in the work-up of patients with tracheal cancer. Toward this goal, centralization of care concerning tracheal tumors is advised. Centralization may increase long-term survival and decrease operative morbidity and mortality even further.
Primary tracheal tumors pose a diagnostic and therapeutic challenge for the physician when confronted with this mostly malignant tumor. Diagnosis is often delayed for months or years due to its aspecific and asthma-mimicking symptoms. Knowledge from retrospective series is limited and few clinicians have gained experience with this tumor. The available literature on the diagnosis and management of this group of tumors is reviewed to summarize the available knowledge about these uncommon tumors. New diagnostic, staging, and treatment guidelines are proposed.
PubMed was searched for English publications from 1960. The available literature was reviewed and summarized.
Surgical resection and primary reconstruction is the best curative treatment modality available at present. In centers of experience, more than half of all patients with tracheal cancer may be candidates for surgical resection, although in population-based studies this treatment is applied in only 10-25% of patients.
在气管癌患者的检查过程中，选择适合手术治疗的患者很重要。为实现这一目标，建议对气管肿瘤的治疗进行集中管理。集中管理可能会提高长期生存率，并进一步降低手术发病率和死亡率。
原发性气管肿瘤对医生来说是一种诊断和治疗上的挑战，因为面对的大多是恶性肿瘤。由于其非特异性且类似哮喘的症状，诊断往往会延迟数月或数年。回顾性系列研究的知识有限，很少有临床医生有处理这种肿瘤的经验。本文对有关这类肿瘤诊断和治疗的现有文献进行综述，以总结关于这些罕见肿瘤的现有知识，并提出新的诊断、分期和治疗指南。
检索PubMed中1960年以来的英文出版物。对现有文献进行综述和总结。
手术切除和一期重建是目前可用的最佳根治性治疗方式。在有经验的中心，超过一半的气管癌患者可能适合手术切除，尽管在基于人群的研究中，这种治疗仅应用于10%-25%的患者。
