Zhou Huaqiang, Tan Wulin, Qiu Zeting, Song Yiyan, Gao Shaowei
Department of Anesthesia, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
PeerJ. 2018 Feb 12;6:e4354. doi: 10.7717/peerj.4354. eCollection 2018.
We aimed to evaluate the global scientific output of gene research of myocardial infarction and explore their hotspots and frontiers from 2001 to 2015, using bibliometric methods.
Articles about the gene research of myocardial infarction between 2001 and 2015 were retrieved from the Web of Science Core Collection (WoSCC). We used the bibliometric method and Citespace V to analyze publication years, journals, countries, institutions, research areas, authors, research hotspots, and trends. We plotted the reference co-citation network, and we used key words to analyze the research hotspots and trends.
We identified 1,853 publications on gene research of myocardial research from 2001 to 2015, and the annual publication number increased with time. Circulation published the highest number of articles. United States ranked highest in the countries with most publications, and the leading institute was Harvard University. Relevant publications were mainly in the field of Cardiovascular system cardiology. Keywords and references analysis indicated that gene expression, microRNA and young women were the research hotspots, whereas stem cell, chemokine, inflammation and cardiac repair were the frontiers.
We depicted gene research of myocardial infarction overall by bibliometric analysis. Mesenchymal stem cells Therapy, MSCs-derived microRNA and genetic modified MSCs are the latest research frontiers. Related studies may pioneer the future direction of this filed in next few years. Further studies are needed.
我们旨在运用文献计量学方法，评估2001年至2015年心肌梗死基因研究的全球科学产出，并探索其热点和前沿领域。
从科学引文索引核心合集（WoSCC）中检索2001年至2015年期间关于心肌梗死基因研究的文章。我们使用文献计量学方法和Citespace V软件分析出版年份、期刊、国家、机构、研究领域、作者、研究热点和趋势。我们绘制了参考文献共被引网络，并使用关键词分析研究热点和趋势。
我们确定了2001年至2015年期间1853篇关于心肌梗死基因研究的出版物，且年发表数量随时间增加。《循环》杂志发表的文章数量最多。美国在发表文章最多的国家中排名第一，领先机构是哈佛大学。相关出版物主要集中在心血管系统心脏病学领域。关键词和参考文献分析表明，基因表达、微小RNA和年轻女性是研究热点，而干细胞、趋化因子、炎症和心脏修复是前沿领域。
我们通过文献计量分析全面描述了心肌梗死的基因研究情况。间充质干细胞治疗、间充质干细胞衍生的微小RNA和基因修饰的间充质干细胞是最新的研究前沿。相关研究可能引领未来几年该领域的发展方向。仍需进一步研究。
