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Knowledge domain and hotspots concerning photosensitive hydrogels for tissue engineering applications: A bibliometric and visualized analysis (1996-2022).

作者信息

Fu Hongxun, Yu Baojun, Wang Hao, Tong Haibin, Jiang Lin, Zhang Yupeng, Meng Guixian, Sun Meiyan, Lin Jieqiong

机构信息

Key Laboratory of Micro/Nano and Ultra-precision Manufacturing, Jilin Province, School of Mechatronic Engineering, Changchun University of Technology, Changchun, China.

College of Laboratory Medicine, Jilin Medical University, Jilin, China.

出版信息

Front Bioeng Biotechnol. 2022 Nov 14;10:1067111. doi: 10.3389/fbioe.2022.1067111. eCollection 2022.


DOI:10.3389/fbioe.2022.1067111
PMID:36466359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9709615/
Abstract

The aim of tissue engineering (TE) is to replace the damaged tissues or failed organs, or restore their missing functions. The important means to achieve this aim is to integrate biomaterials and life elements. Hydrogels are very attractive biomaterials in the field of TE. In particular, engineering extracellular matrices (ECMs) formed by photosensitive hydrogels have captivated much attention, because photopolymerization has many advantages over traditional polymerization approaches, such as rapidity of reaction, spatiotemporal controllability of polymerization process, and operability at physiological temperature, especially it can realize the fabrications of engineering ECMs in the presence of living cells. There have been many excellent reviews on the applications of photosensitive hydrogels in TE in recent years, however, it is inevitable that researchers may have left out many important facts due to exploring the literature from one or a few aspects. It is also a great challenge for researchers to explore the internal relationships among countries, institutions, authors, and references from a large number of literatures in related fields. Therefore, bibliometrics may be a powerful tool to solve the above problems. A bibliometric and visualized analysis of publications concerning the photosensitive hydrogels for TE applications was performed, and the knowledge domain, research hotspots and frontiers in this topic were identified according to the analysis results. We identified and retrieved the publications regarding the photosensitive hydrogels for TE applications between 1996 and 2022 from Web of Science Core Collection (WoSCC). Bibliometric and visualized analysis employing CiteSpace software and R-language package Bibliometrix were performed in this study. 778 publications meeting the eligibility criteria were identified and retrieved from WoSCC. Among those, 2844 authors worldwide participated in the studies in this field, accompanied by an average annual article growth rate of 15.35%. The articles were co-authored by 800 institutions from 46 countries/regions, and the United States published the most, followed by China and South Korea. As the two countries that published the most papers, the United States and China could further strengthen cooperation in this field. Univ Colorado published the most articles ( = 150), accounting for 19.28% of the total. The articles were distributed in 112 journals, among which Biomaterials ( = 66) published the most articles, followed by Acta Biomaterialia ( = 54) and Journal of Biomedical Materials Research Part A ( = 42). The top 10 journals published 47.8% of the 778 articles. The most prolific author was Anseth K ( = 33), followed by Khademhosseini A ( = 29) and Bryant S ( = 22). A total of 1443 keywords were extracted from the 778 articles and the keyword with the highest centrality was "extracellular matrix" (centrality: 0.12). The keywords appeared recently with strong citation bursts were "gelatin", "3d printing" and "3d bioprinting", representing the current research hotspots in this field. "Gelma", "3d printing" and "thiol-ene" were the research frontiers in recent years. This bibliometric and visualized study offered a comprehensive understanding of publications regarding the photosensitive hydrogels for TE applications from 1996 to 2022, including the knowledge domain, research hotspots and frontiers in this filed. The outcome of this study would provide insights for scholars in the related research filed.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/0e53029c57cf/fbioe-10-1067111-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/f931b82e0284/fbioe-10-1067111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/7771a8837067/fbioe-10-1067111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/e04464d42677/fbioe-10-1067111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/1e69d19667a0/fbioe-10-1067111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/2671dcf32a0c/fbioe-10-1067111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/948c64adeaec/fbioe-10-1067111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/82437317a37f/fbioe-10-1067111-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/25f94f3a8ab9/fbioe-10-1067111-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/0e53029c57cf/fbioe-10-1067111-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/f931b82e0284/fbioe-10-1067111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/7771a8837067/fbioe-10-1067111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/e04464d42677/fbioe-10-1067111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/1e69d19667a0/fbioe-10-1067111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/2671dcf32a0c/fbioe-10-1067111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/948c64adeaec/fbioe-10-1067111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/82437317a37f/fbioe-10-1067111-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/25f94f3a8ab9/fbioe-10-1067111-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e29/9709615/0e53029c57cf/fbioe-10-1067111-g009.jpg

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引用本文的文献

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3D micro/nano hydrogel structures fabricated by two-photon polymerization for biomedical applications.

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[2]
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本文引用的文献

[1]
Knowledge domain and hotspots analysis concerning applications of two-photon polymerization in biomedical field: A bibliometric and visualized study.

Front Bioeng Biotechnol. 2022-9-30

[2]
Two-photon polymerization for 3D biomedical scaffolds: Overview and updates.

Front Bioeng Biotechnol. 2022-8-22

[3]
Bibliometric Analysis Reveals a 20-Year Research Trend for Chemotherapy-Induced Peripheral Neuropathy.

Front Neurol. 2022-2-8

[4]
Biomimetic Joint Paint for Efficient Cartilage Repair by Simultaneously Regulating Cartilage Degeneration and Regeneration in Pigs.

ACS Appl Mater Interfaces. 2021-11-24

[5]
A bibliometric of publication trends in medical image segmentation: Quantitative and qualitative analysis.

J Appl Clin Med Phys. 2021-10

[6]
Assessing monocyte phenotype in poly(-glutamic acid) hydrogels formed by orthogonal thiol-norbornene chemistry.

Biomed Mater. 2021-5-28

[7]
A bibliometric analysis of global research output on network meta-analysis.

BMC Med Inform Decis Mak. 2021-5-3

[8]
Thiol-norbornene gelatin hydrogels: influence of thiolated crosslinker on network properties and high definition 3D printing.

Biofabrication. 2020-12-31

[9]
FLASH: Fluorescently LAbelled Sensitive Hydrogel to monitor bioscaffolds degradation during neocartilage generation.

Biomaterials. 2021-1

[10]
Designing Gelatin Methacryloyl (GelMA)-Based Bioinks for Visible Light Stereolithographic 3D Biofabrication.

Macromol Biosci. 2021-1

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