Krishnan Sowmya, Anderson Michael P, Fields David A, Misra Madhusmita
Department of Pediatrics, University of Oklahoma Health Sciences Center, Harold Hamm Diabetes Center, Oklahoma City, OK 73104, United States.
College of Public Health, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, United States.
World J Clin Pediatr. 2018 Feb 8;7(1):43-48. doi: 10.5409/wjcp.v7.i1.43.
To determine the effect of childhood obesity and insulin resistance on bone health.
We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/obese or normal weight. Participants were Tanner 3 or above for pubertal stage, and had fasting blood work done to measure glucose, insulin, C-reactive protein and lipid levels. Homeostatic model of insulin resistance (HOMA-IR) was calculated using the formula (Fasting Blood Glucose *Insulin/405). Body composition and bone mineral density were measured using dual energy X-ray absorptiometry (DXA; Hologic QDR 4500, Waltham, MA, United Kingdom).
Percent trunk fat was associated inversely with whole body bone mineral content (BMC), whereas HOMA-IR was associated positively with whole body BMC.
Our results suggest that abdominal adiposity may have an adverse effect on whole body bone parameters and that this effect is not mediated by insulin resistance.
确定儿童肥胖和胰岛素抵抗对骨骼健康的影响。
我们对13至20岁的青春期青少年和年轻成年人进行了一项横断面研究，这些人要么超重/肥胖，要么体重正常。参与者青春期阶段为坦纳3期或以上，并进行了空腹血液检查以测量血糖、胰岛素、C反应蛋白和血脂水平。使用公式（空腹血糖*胰岛素/405）计算胰岛素抵抗稳态模型（HOMA-IR）。使用双能X线吸收法（DXA；Hologic QDR 4500，美国马萨诸塞州沃尔瑟姆）测量身体成分和骨密度。
躯干脂肪百分比与全身骨矿物质含量（BMC）呈负相关，而HOMA-IR与全身BMC呈正相关。
我们的结果表明，腹部肥胖可能对全身骨骼参数产生不利影响，且这种影响不是由胰岛素抵抗介导的。
