Bello-Hernández Yesenia, Espinoza-Hernández Jessica, Moreno-Coutiño Gabriela
Sección de Micología y, Hospital General "Dr. Manuel Gea González," Mexico City, Mexico.
Sección de Dermatopatología, Hospital General "Dr. Manuel Gea González," Mexico City, Mexico.
Skin Appendage Disord. 2018 Jan;4(1):25-28. doi: 10.1159/000477742. Epub 2017 Jul 6.
Topiramate is an antiepileptic drug that can also be used for migraine prophylaxis, weight control, and even for methamphetamine dependence; the dosage margin is wide, and the list of side effects is shorter than with other anticonvulsants. We present the case of a 35-year-old man with a disseminated rash of the trunk and extremities after treatment with 25 mg of topiramate daily as a prophylactic migraine treatment. This case report is useful, as this patient was not polymedicated and had a score of 7 on the Naranjo Adverse Drug Reaction Probability Scale. The patient was diagnosed as atypical DRESS syndrome and resolved satisfactorily with symptomatic treatment and topiramate withdrawal; slowly, the lesions regressed. He required no further drugs for the dermatologic condition.
托吡酯是一种抗癫痫药物，也可用于偏头痛预防、体重控制，甚至用于甲基苯丙胺成瘾；其剂量范围广，副作用清单比其他抗惊厥药短。我们报告一例35岁男性病例，该患者在每日服用25毫克托吡酯作为偏头痛预防性治疗后，出现躯干和四肢弥漫性皮疹。本病例报告很有价值，因为该患者未使用多种药物，且在纳伦霍药物不良反应概率量表上得分为7分。该患者被诊断为非典型药物超敏反应综合征，经对症治疗和停用托吡酯后症状得到满意缓解；皮疹逐渐消退。他的皮肤病况无需进一步用药。
