Kuhlman D S, Callen J P
Cutis. 1986 Sep;38(3):203-6.
The efficacy and skin tolerance of 1 percent clindamycin phosphate lotion were compared with those of the placebo for the lotion in a randomized, double-blind, 12-week study in forty-six patients with moderate to severe acne vulgaris. Patients using the 1 percent clindamycin lotion experienced reductions in numbers of pustules, papules, open comedones, and nodulocystic lesions. Papule counts were also reduced in placebo-treated patients. The group using clindamycin lotion had significantly greater reductions in pustule counts at week 12 and papule counts at week 3 than the placebo-treated group. Nearly 90 percent of the evaluable patients at week 12 experienced improvement or marked improvement in their acne according to the physician's evaluation, regardless of treatment group. Both regimens were well tolerated. Although diarrhea was reported by eight patients (three taking clindamycin, five receiving placebo), no patients discontinued the protocol because of diarrhea. This study demonstrated the efficacy of 1 percent clindamycin topical lotion in the treatment of moderate to severe acne vulgaris.
在一项针对46例中度至重度寻常痤疮患者的随机、双盲、为期12周的研究中，将1%克林霉素磷酸酯洗剂的疗效和皮肤耐受性与该洗剂的安慰剂进行了比较。使用1%克林霉素洗剂的患者脓疱、丘疹、开放性粉刺和结节囊肿性损害的数量减少。接受安慰剂治疗的患者丘疹数量也减少。使用克林霉素洗剂的组在第12周时脓疱数量的减少以及在第3周时丘疹数量的减少均显著大于接受安慰剂治疗的组。根据医生的评估，在第12周时，近90%可评估的患者无论治疗组如何，痤疮均有改善或明显改善。两种治疗方案耐受性均良好。尽管有8例患者报告腹泻（3例服用克林霉素，5例接受安慰剂），但没有患者因腹泻而停止治疗方案。本研究证明了1%克林霉素外用洗剂治疗中度至重度寻常痤疮的疗效。
