1 Division of Dermatology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
2 Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
J Cutan Med Surg. 2018 Sep/Oct;22(5):516-518. doi: 10.1177/1203475418760457. Epub 2018 Feb 18.
Polyarteritis nodosa (PAN) is a rare vasculitis affecting medium-sized vessels. Cutaneous PAN is a clinical variant, and we report the first case of empagliflozin-induced cutaneous PAN in a 69-year-old man. After starting empagliflozin, the patient presented with tender subcutaneous nodules on his legs, which showed a medium-sized vessel vasculitis on histopathology. Upon cessation of this medication, he had full resolution of these nodules. This case illustrates that empagliflozin can induce cutaneous PAN, and further attention to this medication's association with cutaneous PAN is warranted.
结节性多动脉炎（PAN）是一种罕见的影响中等大小血管的血管炎。皮肤型 PAN 是一种临床变异型，我们报告了首例恩格列净引起的 69 岁男性皮肤型 PAN 病例。开始使用恩格列净后，该患者腿部出现触痛性皮下结节，组织病理学显示中等大小血管血管炎。停止使用该药后，这些结节完全消退。该病例表明，恩格列净可引起皮肤型 PAN，需要进一步关注该药与皮肤型 PAN 的关联性。
