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心脏肿瘤学:先进超声心动图在癌症患者中的作用

Cardio-oncology: the role of advanced echocardiography in cancer patients.

作者信息

Venneri Lucia, Zoppellaro Giacomo, Khattar Rajdeep S

机构信息

a Department of Echocardiography , Royal Brompton Hospital , London , UK.

出版信息

Expert Rev Cardiovasc Ther. 2018 Apr;16(4):249-258. doi: 10.1080/14779072.2018.1443394. Epub 2018 Feb 22.

Abstract

Cardio-oncology is a rapidly growing field aimed at improving the quality of care of cancer patients by preventing and monitoring cardiovascular complications resulting from cancer treatment. Cardiac imaging, and in particular, transthoracic echocardiography, plays an essential
role in the baseline assessment and serial follow-up of cardio-oncology patients. Areas covered: This review article discusses the role of cardiac imaging with a focus on advanced echocardiography for the detection and management of cancer therapy related cardiovascular complications, in particular, left ventricular dysfunction and heart failure. Expert commentary: While traditional imaging based assessment of left ventricular ejection fraction still has its place in cardiac monitoring, more advanced echocardiographic modalities, in particular, myocardial deformation imaging with speckle tracking strain analysis, show great potential for detecting early signs of cardiotoxicity. Larger studies are needed to determine both the clinical role of strain measurement in influencing initiation of cardioprotective agents and its prognostic value in long term outcome.

摘要

心脏肿瘤学是一个快速发展的领域,旨在通过预防和监测癌症治疗引起的心血管并发症来提高癌症患者的护理质量。心脏成像,尤其是经胸超声心动图,在心脏肿瘤学患者的基线评估和系列随访中起着至关重要的作用。涵盖领域:本文综述讨论了心脏成像的作用,重点是先进的超声心动图在检测和管理癌症治疗相关心血管并发症,特别是左心室功能障碍和心力衰竭方面的应用。专家评论:虽然基于传统成像的左心室射血分数评估在心脏监测中仍有其地位,但更先进的超声心动图模式,特别是采用斑点追踪应变分析的心肌变形成像,在检测心脏毒性早期迹象方面显示出巨大潜力。需要进行更大规模的研究,以确定应变测量在影响心脏保护药物启动方面的临床作用及其对长期预后的预测价值。

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