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心脏毒性中的心脏成像:聚焦临床实践

Cardiac imaging in cardiotoxicity: a focus on clinical practice.

作者信息

Makavos George, Ikonomidis Ignatios, Palios John, Rigopoulos Angelos, Katogiannis Konstantinos, Parissis John, Paraskevaidis Ioannis, Noutsias Michel

机构信息

2nd Department of Cardiology, "Attikon" Hospital, National and Kapodistrian University of Athens Medical School, Rimini 1, Haidari, 12462, Athens, Greece.

Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle (Saale), Germany.

出版信息

Heart Fail Rev. 2021 Sep;26(5):1175-1187. doi: 10.1007/s10741-020-09952-w.

Abstract

Cancer therapeutics induced cardiotoxicity has emerged as an important factor of long-term adverse cardiovascular outcomes in survivors of various malignant diseases. Early detection of myocardial injury in the setting of cancer treatment is important for the initiation of targeted cardioprotective therapy, in order to prevent irreversible cardiac dysfunction and heart failure, while not withholding a potentially life-saving cancer therapy. Cardiac imaging techniques including echocardiography, cardiac magnetic resonance, and nuclear cardiac imaging are the main tools for the identification of cardiotoxicity. There is also growing evidence for the detection of subclinical cardiac dysfunction in cancer patients by speckle tracking echocardiography. In this review article, we focus on current and emerging data regarding the role of cardiac imaging for the detection of changes in myocardial function related with cancer treatment in clinical practice.

摘要

癌症治疗引起的心脏毒性已成为各种恶性疾病幸存者长期不良心血管结局的一个重要因素。在癌症治疗过程中早期检测心肌损伤对于启动有针对性的心脏保护治疗很重要,这样既能预防不可逆的心脏功能障碍和心力衰竭,又不会停止可能挽救生命的癌症治疗。包括超声心动图、心脏磁共振成像和核心脏成像在内的心脏成像技术是识别心脏毒性的主要工具。越来越多的证据表明,斑点追踪超声心动图可用于检测癌症患者的亚临床心脏功能障碍。在这篇综述文章中,我们重点关注有关心脏成像在临床实践中检测与癌症治疗相关的心肌功能变化作用的现有和新出现的数据。

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