Programa de Pós-Graduação em Biotecnologia (PPGB), Grupo de Pesquisa em Oncologia Celular e Molecular, Laboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Programa de Pós-Graduação em Biotecnologia (PPGB), Grupo de Pesquisa em Oncologia Celular e Molecular, Laboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Chem Biol Interact. 2018 Apr 1;285:69-75. doi: 10.1016/j.cbi.2018.02.021. Epub 2018 Feb 16.
All-trans retinoic acid (ATRA), a derivative of vitamin A, has been shown to potentiate cancer chemotherapy due to its ability to induce signals for cell differentiation or death, and inhibit cell proliferation. The combination of ATRA with taxoids, kinase inhibitors, natural compounds, retinoids, ER or HER2 inhibitors, chemotherapeutic drugs, proteasome inhibitors and nanoformulations of tretinoin have demonstrated additive or synergistic effects in anti-cancer activities. The mechanisms by which the compounds exert their synergistic effects depend on the tumor and the cell type. However, several experiments demonstrated similar mechanisms such as reduction of PCK, c-myc, E2F and Bcl-2, as well as increase of p21 and TGF-β. When the apoptotic synergistic effect was observed, the predominant effect of ATRA was in differentiation induction. The results indicate that future combinations of ATRA and anti-tumor agents hold promise to enhance and improve anti-carcinogenic therapies.
全反式维甲酸（ATRA）是维生素 A 的衍生物，由于其诱导细胞分化或死亡信号以及抑制细胞增殖的能力，已被证明能增强癌症化疗的效果。ATRA 与紫杉烷类、激酶抑制剂、天然化合物、维甲酸、ER 或 HER2 抑制剂、化疗药物、蛋白酶体抑制剂和维甲酸的纳米制剂联合使用，在抗癌活性方面表现出相加或协同作用。化合物发挥协同作用的机制取决于肿瘤和细胞类型。然而，一些实验表明存在相似的机制，如降低 PCK、c-myc、E2F 和 Bcl-2，以及增加 p21 和 TGF-β。当观察到凋亡协同作用时，ATRA 的主要作用是诱导分化。结果表明，未来 ATRA 与抗肿瘤药物的联合应用有望增强和改善抗癌治疗。
