Hołda Mateusz K, Hołda Jakub, Koziej Mateusz, Piątek Katarzyna, Klimek-Piotrowska Wiesława
HEART - Heart Embryology and Anatomy Research Team, Jagiellonian University Medical College, Cracow, Poland.
HEART - Heart Embryology and Anatomy Research Team, Jagiellonian University Medical College, Cracow, Poland.
Ann Anat. 2018 May;217:24-28. doi: 10.1016/j.aanat.2018.01.002. Epub 2018 Feb 16.
The left-sided atrial septal pouch (SP), a recently re-discovered anatomical structure within the human interatrial septum, has emerged as a possible source of thrombi formation and a trigger for atrial fibrillation, thereby potentially increasing the risk for ischemic stroke. In many studies, the swine interatrial septum has been used as model of the human heart. Also, possible new strategies and devices for management of the SPs may first be tested in this pig model. Therefore, in this study, we aimed to evaluate swine interatrial septum morphology and to compare it with the human analog, especially in the light of SP occurrence.
A total of 75 swine (Sus scrofa f. domestica) hearts were examined. The interatrial septum morphology was assessed, and SPs were measured.
The most common variant of the interatrial septum was smooth septum (26.6%) followed by the patent foramen ovale channel and right SP (both 22.7%). No left or double SPs were observed. In 28.0% of all cases the fold of tissue (left septal ridge) was observed on the left side of the interatrial septum in the location where the left-sided SP should be expected. The mean length of the patent foramen ovale channel was 7.1±1.5mm. The mean right SP depth was 6.3±2.2mm, and its ostium width and height were 5.8±1.2 and 5.3±1.6mm, respectively.
There are significant differences between human and porcine interatrial septum morphology that should be taken into account during experimental studies. The absence of the left SP in swine results in the inability to use porcine heart as an experimental model for left-sided SP management.
左侧房间隔袋（SP）是人类房间隔内最近重新发现的一种解剖结构，已成为血栓形成的可能来源和心房颤动的触发因素，从而可能增加缺血性中风的风险。在许多研究中，猪的房间隔已被用作人类心脏的模型。此外，针对房间隔袋的可能新策略和装置可能首先在这种猪模型中进行测试。因此，在本研究中，我们旨在评估猪房间隔的形态，并将其与人类相应结构进行比较，特别是鉴于房间隔袋的出现情况。
共检查了75个猪（家猪）心脏。评估房间隔形态并测量房间隔袋。
房间隔最常见的变体是平滑间隔（26.6%），其次是卵圆孔未闭通道和右侧房间隔袋（均为22.7%）。未观察到左侧或双侧房间隔袋。在所有病例的28.0%中，在房间隔左侧预期左侧房间隔袋的位置观察到组织褶皱（左侧间隔嵴）。卵圆孔未闭通道的平均长度为7.1±1.5mm。右侧房间隔袋的平均深度为6.3±2.2mm，其开口宽度和高度分别为5.8±1.2mm和5.3±1.6mm。
人和猪房间隔形态存在显著差异，在实验研究中应予以考虑。猪不存在左侧房间隔袋，导致无法将猪心脏用作左侧房间隔袋处理的实验模型。
