Li Da-Ke, Liu Feng-Tao, Chen Kui, Bu Lu-Lu, Yang Ke, Chen Chen, Liu Zhen-Yang, Tang Yi-Lin, Zhao Jue, Sun Yi-Min, Wang Jian, Wu Jian-Jun
From the Department of Neurology and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China (D-KL, F-TL, KC, L-LB, KY, CC, Z-YL, Y-LT, JZ, Y-MS, JW, J-JW).
J Neuropsychiatry Clin Neurosci. 2018 Spring;30(2):122-129. doi: 10.1176/appi.neurospych.17030063. Epub 2018 Feb 20.
Depressive symptoms and sensory dysfunction, such as reduction in visual and olfactory function, are common in Parkinson's disease (PD). Previous studies have suggested that depressive symptoms are associated with visual impairments and potentially with hyposmia in several types of mood disorders. However, the relationship between depressive symptoms and sensory dysfunction remains unclear in PD. To examine the association of depressive symptoms with color vision and olfactory function in PD, the authors conducted a cross-sectional study in 159 patients with PD. Depressive symptoms were measured with the Beck Depression Inventory-II (BDI-II) and the 30-item Geriatric Depression Scale (GDS-30); color vision was tested with the Farnsworth-Munsell 100 Hue Test (FMT); and olfactory function was tested with the Sniffin' Sticks Screening 12 Test. Results showed that the total error score (TES) for the FMT was significantly and independently correlated with scores on both the BDI-II and GDS-30 in a positive manner, suggesting that more severe depressive symptoms are associated with poorer color vision in PD. In addition, both somatic and effective subscores for the BDI-II were correlated with the TES on the FMT, while no significant correlation was observed between total scores on the Sniffin' Sticks Screening 12 Test and BDI-II or GDS-30. The decrease in color vision but not olfactory function was found to be associated with the severity of depressive symptoms in PD patients, supporting the idea that the occurrence of depressive symptoms in PD is linked with disruption of the visual system.
抑郁症状和感觉功能障碍，如视觉和嗅觉功能减退，在帕金森病（PD）中很常见。先前的研究表明，抑郁症状与几种情绪障碍中的视觉障碍以及潜在的嗅觉减退有关。然而，在帕金森病中，抑郁症状与感觉功能障碍之间的关系仍不清楚。为了研究帕金森病患者抑郁症状与色觉和嗅觉功能的关系，作者对159例帕金森病患者进行了一项横断面研究。使用贝克抑郁量表第二版（BDI-II）和30项老年抑郁量表（GDS-30）测量抑郁症状；使用法恩斯沃思-芒塞尔100色调测试（FMT）测试色觉；使用嗅觉棒筛查12项测试测试嗅觉功能。结果显示，FMT的总错误分数（TES）与BDI-II和GDS-30的分数均呈显著正相关，这表明在帕金森病中，更严重的抑郁症状与较差的色觉有关。此外，BDI-II的躯体和效价子分数均与FMT上的TES相关，而嗅觉棒筛查12项测试的总分与BDI-II或GDS-30之间未观察到显著相关性。研究发现，帕金森病患者色觉下降而非嗅觉功能下降与抑郁症状的严重程度相关，这支持了帕金森病中抑郁症状的发生与视觉系统紊乱有关的观点。
