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Updates on cardiovascular outcome trials in diabetes.糖尿病心血管结局试验的最新进展。
Cardiovasc Diabetol. 2017 Oct 11;16(1):128. doi: 10.1186/s12933-017-0610-y.
2
Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial.阿卡波糖对冠心病合并糖耐量受损患者心血管和糖尿病结局的影响(ACE):一项随机、双盲、安慰剂对照试验。
Lancet Diabetes Endocrinol. 2017 Nov;5(11):877-886. doi: 10.1016/S2213-8587(17)30309-1. Epub 2017 Sep 13.
3
Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.每周一次艾塞那肽对2型糖尿病患者心血管结局的影响。
N Engl J Med. 2017 Sep 28;377(13):1228-1239. doi: 10.1056/NEJMoa1612917. Epub 2017 Sep 14.
4
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease.载脂蛋白 AI 模拟肽(Anacetrapib)在动脉粥样硬化性血管疾病患者中的作用。
N Engl J Med. 2017 Sep 28;377(13):1217-1227. doi: 10.1056/NEJMoa1706444. Epub 2017 Aug 28.
5
Understanding the Gap Between Efficacy in Randomized Controlled Trials and Effectiveness in Real-World Use of GLP-1 RA and DPP-4 Therapies in Patients With Type 2 Diabetes.理解 GLP-1RA 和 DPP-4 治疗药物在 2 型糖尿病患者中的随机对照试验疗效与真实世界应用效果之间的差距。
Diabetes Care. 2017 Nov;40(11):1469-1478. doi: 10.2337/dc16-2725. Epub 2017 Aug 11.
6
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.卡格列净与 2 型糖尿病的心血管和肾脏事件。
N Engl J Med. 2017 Aug 17;377(7):644-657. doi: 10.1056/NEJMoa1611925. Epub 2017 Jun 12.
7
Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.德谷胰岛素与甘精胰岛素治疗2型糖尿病的疗效和安全性比较
N Engl J Med. 2017 Aug 24;377(8):723-732. doi: 10.1056/NEJMoa1615692. Epub 2017 Jun 12.
8
Lower Risk of Heart Failure and Death in Patients Initiated on Sodium-Glucose Cotransporter-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotransporter-2 Inhibitors).与其他降糖药物相比,起始使用钠-葡萄糖协同转运蛋白2抑制剂的患者发生心力衰竭和死亡的风险更低:CVD-REAL研究(钠-葡萄糖协同转运蛋白2抑制剂新使用者心血管结局的比较有效性)
Circulation. 2017 Jul 18;136(3):249-259. doi: 10.1161/CIRCULATIONAHA.117.029190. Epub 2017 May 18.
9
Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease.依洛尤单抗与心血管疾病患者的临床结局。
N Engl J Med. 2017 May 4;376(18):1713-1722. doi: 10.1056/NEJMoa1615664. Epub 2017 Mar 17.
10
Report from the 2nd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes and Cardiovascular Disease (D&CVD) EASD Study Group.糖尿病与心血管疾病(D&CVD)欧洲糖尿病研究学会(EASD)研究组第二届心血管结局试验(CVOT)峰会报告。
Cardiovasc Diabetol. 2017 Mar 11;16(1):35. doi: 10.1186/s12933-017-0508-8.

第三届心血管结局试验(CVOT)峰会报告——糖尿病与心血管疾病(D&CVD)EASD 研究组。

Report from the 3rd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D&CVD) EASD Study Group.

机构信息

Forschergruppe Diabetes e.V., Munich, Ingolstaedter Landstrasse 1, Neuherberg, 85764, Munich, Germany.

Internal Medicine Department, Clinical County Emergency Hospital Constanta, Tomis Blvd. No. 145, 900591, Constanta, Romania.

出版信息

Cardiovasc Diabetol. 2018 Feb 19;17(1):30. doi: 10.1186/s12933-018-0667-2.

DOI:10.1186/s12933-018-0667-2
PMID:29458368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5819256/
Abstract

The 3rd Cardiovascular Outcome Trial Summit of the Diabetes & Cardiovascular Disease EASD Study Group was held on the 26-27 October 2017 in Munich. As in 2015 and 2016, this summit was organised in light of recently completed and published CVOTs on diabetes, aiming to serve as a reference meeting for in-depth discussions on the topic. Amongst others, the CVOTs EXSCEL, DEVOTE, the CANVAS program and the ACE-trial, which released primary outcome results in 2017, were discussed. Trial implications for diabetes management and recent perspectives of diabetologists, cardiologists, endocrinologists, nephrologists and general practitioners were highlighted. The clinical relevance of cardiovascular outcome trials and its implications regarding reimbursement were compared with real-world studies. The 4th Cardiovascular Outcome Trial Summit will be held in Munich 25-26 October 2018 ( http://www.dcvd.org ).

摘要

第三届糖尿病与心血管疾病 EASD 研究组心血管结局试验峰会于 2017 年 10 月 26 日至 27 日在慕尼黑举行。与 2015 年和 2016 年一样,本次峰会是根据最近完成并发表的糖尿病心血管结局试验组织召开的,旨在为深入讨论该主题提供参考。其中讨论了 EXSCEL、DEVOTE、CANVAS 计划和 ACE 试验,这些试验在 2017 年公布了主要结局结果。还强调了试验对糖尿病管理的影响以及糖尿病专家、心脏病专家、内分泌专家、肾病专家和全科医生的最新观点。心血管结局试验的临床相关性及其与实际研究相比的报销意义进行了比较。第四届心血管结局试验峰会将于 2018 年 10 月 25 日至 26 日在慕尼黑举行(http://www.dcvd.org)。