泰国一家阴道镜诊所中用于检测高危型人乳头瘤病毒感染的自行采集样本与医生采集样本的一致性
Agreement of self- and physician-collected samples for detection of high-risk human papillomavirus infections in women attending a colposcopy clinic in Thailand.
作者信息
Phoolcharoen Natacha, Kantathavorn Nuttavut, Krisorakun Wasanai, Sricharunrat Thaniya, Teerayathanakul Narongchai, Taepisitpong Chantanee, Sornsamdang Gaidganok, Krongthong Waraphorn, Saeloo Siriporn
机构信息
Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Road, Pathum Wan, Bangkok, 10330, Thailand.
出版信息
BMC Res Notes. 2018 Feb 20;11(1):136. doi: 10.1186/s13104-018-3241-9.
Abstract
OBJECTIVE
To study the concordance between vaginal self- and endocervical physician-collected high-risk (hr) HPV testing in Thai women who attended a colposcopy clinic. Vaginal samples were obtained by self-sampling with a dry brush before endocervical samples were obtained by physicians. Both specimens were analyzed for hrHPV by Cobas4800 HPV test.
RESULTS
Of the 247 pairs of samples, overall hrHPV prevalence from self- and physician-collected samples was 41.3 and 36.0%, respectively. The overall agreement between the methods was 74.5% with κ 0.46 (P < 0.001). Our study revealed moderate agreement between self- and physician-collected methods for hrHPV testing.
摘要
目的
研究在阴道镜检查诊所就诊的泰国女性中，阴道自我采集与宫颈管医生采集的高危（hr）人乳头瘤病毒（HPV）检测结果的一致性。在医生采集宫颈管样本之前，先用干刷进行自我采样获取阴道样本。两份样本均通过Cobas4800 HPV检测法进行hrHPV分析。
结果
在247对样本中，自我采集样本和医生采集样本的总体hrHPV患病率分别为41.3%和36.0%。两种方法的总体一致性为74.5%，κ值为0.46（P<0.001）。我们的研究表明，自我采集和医生采集方法在hrHPV检测方面存在中度一致性。
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