Strauss J S
J Am Acad Dermatol. 1986 Oct;15(4 Pt 2):905-6. doi: 10.1016/s0190-9622(86)70249-1.
It is clear that tretinoin has a major place in the treatment of acne via its effect on the abnormal pattern of keratinization, the initial pathophysiologic event in the disease. However, for purposes of introduction, it is useful to compare tretinoin with another topical retinoid, motretinide (Ro 11-1430), which is currently used in Europe. Herein is an overview of several studies that have examined the efficacy of these two agents.
显然，维甲酸通过对异常角化模式（该病最初的病理生理事件）的作用，在痤疮治疗中占据重要地位。然而，为便于介绍，将维甲酸与另一种目前在欧洲使用的局部类视黄醇——莫维A胺（Ro 11 - 1430）进行比较是有益的。本文概述了几项研究这两种药物疗效的研究。
