Fernandes Juliano Lara
Jose Michel Kalaf Research Institute, Radiologia Clinica de Campinas, Avenida Jose de Souza Campos 840, Campinas, São Paulo 13092-123, Brazil.
Hematol Oncol Clin North Am. 2018 Apr;32(2):277-295. doi: 10.1016/j.hoc.2017.11.012.
MRI is a key tool in the current management of patients with thalassemia. Given its capability of assessing iron overload in different organs noninvasively and without contrast, it has significant advantages over other metrics, including serum ferritin. Liver iron concentration can be measured either with relaxometry methods T2*/T2 or signal intensity ratio techniques. Myocardial iron can be assessed in the same examination through T2* imaging. In this review, we focus on showing how MRI evaluates iron in both organs and the clinical applications as well as practical approaches to using this tool by clinicians taking care of patients with thalassemia.
磁共振成像（MRI）是目前地中海贫血患者管理中的关键工具。鉴于其能够在不使用造影剂的情况下无创评估不同器官的铁过载情况，与包括血清铁蛋白在内的其他指标相比，它具有显著优势。肝铁浓度可以通过弛豫测量法T2*/T2或信号强度比技术进行测量。在同一次检查中，可以通过T2*成像评估心肌铁含量。在本综述中，我们重点展示MRI如何评估这两个器官中的铁含量、临床应用以及临床医生在照顾地中海贫血患者时使用该工具的实用方法。
