Department of Clinical Pharmacology and Toxicology, Izmir Ataturk Research Hospital, Izmir, Turkey.
Department of Psychiatry, Cigli Regional Training Hospital, Izmir, Turkey.
Complement Ther Med. 2018 Feb;36:30-32. doi: 10.1016/j.ctim.2017.11.008. Epub 2017 Nov 14.
Passiflora incarnata is marketed in many countries as anxiolytic herbal supplement. Herbal medicines are natural products, but it doesn't mean they are always safe, especially during pregnancy. Passiflora incarnata extract was not teratogenic in experimental studies. However, there are no data available on possible effects on human pregnancy. Here we report five pregnant women with depression and/or anxiety who used passiflora incarnata in pregnancy. We observed one pregnancy resulting in neonatal death, two pregnancies with premature rupture of membranes, two infants with meconium aspiration syndrome and one infant with persistent pulmonary hypertension. No birth defects and no growth or developmental abnormalities for the live born infants were reported at 6 months of age. This observation is important since there have been no human reports about the use of passiflora incarnata in pregnant women. Pregnant women exposed to passiflora incarnata should be monitored, unless further data are available.
西番莲在许多国家被作为一种抗焦虑的草本补充剂销售。草药是天然产品，但这并不意味着它们总是安全的，尤其是在怀孕期间。西番莲提取物在实验研究中没有致畸性。然而，目前还没有关于其对人类妊娠可能产生的影响的数据。在这里，我们报告了五例患有抑郁症和/或焦虑症的孕妇在怀孕期间使用西番莲的情况。我们观察到一例新生儿死亡，两例胎膜早破，两例胎粪吸入综合征和一例持续性肺动脉高压。在 6 个月大时，没有报告活产婴儿有出生缺陷或生长发育异常。这一观察结果很重要，因为目前还没有人报告过孕妇使用西番莲的情况。除非有更多的数据，否则应该对接触西番莲的孕妇进行监测。
