骨骼肌边缘空泡中腺苷酸脱氨酶活性较高。
High AMP deaminase activity in rimmed vacuoles of skeletal muscle.
作者信息
Higuchi I, Nonaka I, Ishiura S, Ishihara T, Sugita H
出版信息
J Neurol Sci. 1986 Oct;75(3):329-42. doi: 10.1016/0022-510x(86)90080-8.
Localized high AMP deaminase activity was found in the rimmed vacuoles of skeletal muscles in acid maltase deficiency, distal myopathy with rimmed vacuole formation, and experimental chloroquine myopathy on histochemical staining. Acid phosphatase activity was also increased in and around these vacuoles, but the vacuoles were negative for other histochemical stainings such as with NADH-tetrazolium reductase, ATPase and phosphorylase. These findings suggest that AMP deaminase is bound to membranous components in addition to myosin in skeletal muscle.
在酸性麦芽糖酶缺乏症、伴有镶边空泡形成的远端肌病以及实验性氯喹肌病的骨骼肌镶边空泡中，通过组织化学染色发现了局部高AMP脱氨酶活性。这些空泡及其周围的酸性磷酸酶活性也有所增加，但这些空泡对其他组织化学染色（如NADH-四唑还原酶、ATP酶和磷酸化酶染色）呈阴性。这些发现表明，除了骨骼肌中的肌球蛋白外，AMP脱氨酶还与膜性成分结合。
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