抗癫痫药物引起的骨密度降低可导致雄性Wistar大鼠正畸牙齿移动加速。
Decreased bone density induced by antiepileptic drugs can cause accelerated orthodontic tooth movement in male Wistar rats.
作者信息
Akhoundi Mohammad Sadegh Ahmad, Sheikhzadeh Sedigheh, Mirhashemi Amirhossein, Ansari Elahe, Kheirandish Yasaman, Allaedini Mozhgan, Dehpour Ahmadreza
机构信息
Dental Research Center Dentistry Research Institute, Orthodontics Department, Tehran University of Medical Sciences, Tehran, Iran.
Orthodontics Department, Dental faculty, Babol University of Medical Sciences, Babol, Iran.
出版信息
Int Orthod. 2018 Mar;16(1):73-81. doi: 10.1016/j.ortho.2018.01.021. Epub 2018 Feb 17.
PURPOSE
The aim of the present study was to evaluate the effect of the carbamazepine and valproic acid on orthodontic tooth movement in male Wistar rats.
METHODS
Evaluation of tooth movement after 21 days of drugs infusion was carried out by feeler gauge. Bone densitometry on lateral cephalograms was conducted on days 1 and 21. After dissection of the maxillae, histologic parameters were evaluated.
RESULTS
Orthodontic tooth movement was accelerated in experimental groups rather than controls. Optical density was significantly increased in these groups. In histologic sections, mesioapical portion of the PDL (Periodontal Ligament) was wider in experimental groups. Also, distoapical portion of the PDL was wider only in valproic acid group.
CONCLUSION
Valproic acid and carbamazepine can decrease the bone density which may induce the accelerated orthodontic tooth movement in rats.
目的
本研究旨在评估卡马西平和丙戊酸对雄性Wistar大鼠正畸牙齿移动的影响。
方法
通过塞尺评估药物输注21天后的牙齿移动情况。在第1天和第21天对头颅侧位片进行骨密度测定。上颌骨解剖后，评估组织学参数。
结果
实验组的正畸牙齿移动比对照组加速。这些组的光密度显著增加。在组织学切片中，实验组牙周膜的近中根尖部分更宽。此外，仅丙戊酸组的牙周膜远中根尖部分更宽。
结论
丙戊酸和卡马西平可降低骨密度，这可能导致大鼠正畸牙齿移动加速。
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