磁共振弹性成像评估脑硬度：测量可重复性及其在假性脑瘤患者中的评估

Magnetic resonance elastography to estimate brain stiffness: Measurement reproducibility and its estimate in pseudotumor cerebri patients.

作者信息

Kolipaka Arunark, Wassenaar Peter A, Cha Sangmin, Marashdeh Wael M, Mo Xiaokui, Kalra Prateek, Gans Bradley, Raterman Brian, Bourekas Eric

机构信息

Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

出版信息

Clin Imaging. 2018 Sep-Oct;51:114-122. doi: 10.1016/j.clinimag.2018.02.005. Epub 2018 Feb 11.

DOI:10.1016/j.clinimag.2018.02.005

PMID:29459315

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6087505/

Abstract

This study determines the reproducibility of magnetic resonance elastography (MRE) derived brain stiffness in normal volunteers and compares it against pseudotumor patients before and after lumbar puncture (LP). MRE was performed on 10 normal volunteers for reproducibility and 14 pseudotumor patients before and after LP. During LP, opening and closing cerebrospinal fluid (CSF) pressures were recorded before and after removal of CSF and correlated to brain stiffness. Stiffness reproducibility was observed (r > 0.78; p < 0.008). Whole brain opening LP stiffness was significantly (p = 0.04) higher than normals, but no significant difference (p = 0.11) in closing LP measurements. No significant correlation was observed between opening and closing pressure and brain stiffness.

摘要

本研究确定了磁共振弹性成像（MRE）得出的正常志愿者脑硬度的可重复性，并将其与假性脑瘤患者腰椎穿刺（LP）前后的情况进行比较。对10名正常志愿者进行MRE以评估可重复性，并对14名假性脑瘤患者在LP前后进行MRE。在LP过程中，记录去除脑脊液前后的脑脊液（CSF）开放压和闭合压，并将其与脑硬度相关联。观察到硬度具有可重复性（r > 0.78；p < 0.008）。全脑LP开放时的硬度显著高于正常人（p = 0.04），但LP闭合时的测量结果无显著差异（p = 0.11）。未观察到开放压和闭合压与脑硬度之间存在显著相关性。