Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Br J Radiol. 2021 Mar 1;94(1119):20200265. doi: 10.1259/bjr.20200265.
Brain magnetic resonance elastography (MRE) is an imaging technique capable of accurately and non-invasively measuring the mechanical properties of the living human brain. Recent studies have shown that MRE has potential to provide clinically useful information in patients with intracranial tumors, demyelinating disease, neurodegenerative disease, elevated intracranial pressure, and altered functional states. The objectives of this review are: (1) to give a general overview of the types of measurements that have been obtained with brain MRE in patient populations, (2) to survey the tools currently being used to make these measurements possible, and (3) to highlight brain MRE-based quantitative biomarkers that have the highest potential of being adopted into clinical use within the next 5 to 10 years. The specifics of MRE methodology strategies are described, from wave generation to material parameter estimations. The potential clinical role of MRE for characterizing and planning surgical resection of intracranial tumors and assessing diffuse changes in brain stiffness resulting from diffuse neurological diseases and altered intracranial pressure are described. In addition, the emerging technique of functional MRE, the role of artificial intelligence in MRE, and promising applications of MRE in general neuroscience research are presented.
脑磁共振弹性成像（MRE）是一种能够准确、无创地测量活体人脑机械特性的成像技术。最近的研究表明，MRE 有可能为颅内肿瘤、脱髓鞘疾病、神经退行性疾病、颅内压升高和功能状态改变的患者提供有临床价值的信息。本综述的目的是：（1）概述在患者人群中通过脑 MRE 获得的测量类型；（2）调查目前用于实现这些测量的工具；（3）强调脑 MRE 基于定量生物标志物，它们最有可能在未来 5 到 10 年内被采用到临床应用中。描述了 MRE 方法学策略的细节，从波的产生到材料参数估计。描述了 MRE 在颅内肿瘤的特征和手术切除计划中的潜在临床作用，以及评估弥漫性神经疾病和颅内压改变导致的脑僵硬弥漫性变化。此外，还介绍了功能 MRE 的新兴技术、人工智能在 MRE 中的作用以及 MRE 在一般神经科学研究中的有前途的应用。
