Rohani Farzaneh, Alai Mohammad Reza, Moradi Sedighe, Amirkashani Davoud
Pediatric Growth and Development Research CenterIran University of Medical Sciences, Tehran, Iran
Department of Pediatric Endocrinology and Metabolic DiseasesMofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocr Connect. 2018 Mar;7(3):456-459. doi: 10.1530/EC-18-0043. Epub 2018 Feb 19.
This study was conducted to find out whether boys with constitutional delay in growth and puberty (CDGP) could attain their target height and predicted adult height (PAH) in adulthood or not.
After measuring the height, weight, pubertal stage, parental height and bone age data of the patients at their first presentation were extracted from the files and their height and weight were measured at the end of the study, wrist X-Ray was performed in order to determine the bone age. PAH was calculated using Bayley-Pinneau method and target height was estimated by mid parental height. Final or near final heights of the patients were measured and compared with the target height and PAH.
The mean age at presentation and the end of study was 15.2 ± 0.95, 20 ± 0.75 years respectively. Mean of bone age at the beginning of study was 12.97 ± 1 years and at the end of study were 17.6 ± 0.58 years. Mean of delayed bone age was 2.2 ± 0.82 years. Mean of the primary measured heights was 150.16 ± 7 cm (138-160 cm). Mean of final or near final heights was 165.7 ± 2.89 cm (161-170.5 cm). Final or near final heights in our subjects were smaller than either their PAH (165.7 ± 2.89 vs 170.7 ± 5.17) ( value <0.005) or target height (165.7 ± 2.89 vs 171.8 ± 4.65) ( value <0.0001).
Most patients with CDGP do not reach their target height or predicted adult height; they are usually shorter than their parents and general population. Such patients need to be followed up until they reach their final height and, in some cases, adjunctive medical treatment might be indicated.
本研究旨在确定体质性生长和青春期延迟（CDGP）的男孩在成年后能否达到其靶身高和预测成年身高（PAH）。
在患者首次就诊时测量其身高、体重、青春期阶段、父母身高，并从病历中提取骨龄数据，在研究结束时测量其身高和体重，进行腕部X线检查以确定骨龄。使用贝利-平诺方法计算PAH，并通过父母平均身高估算靶身高。测量患者的最终或接近最终身高，并与靶身高和PAH进行比较。
首次就诊时和研究结束时的平均年龄分别为15.2±0.95岁、20±0.75岁。研究开始时的平均骨龄为12.97±1岁，研究结束时为17.6±0.58岁。骨龄延迟的平均时间为2.2±0.82岁。初次测量身高的平均值为150.16±7cm（138 - 160cm）。最终或接近最终身高的平均值为165.7±2.89cm（161 - 170.5cm）。我们研究对象的最终或接近最终身高低于其PAH（165.7±2.89 vs 170.7±5.17）（P值<0.005）或靶身高（165.7±2.89 vs 171.8±4.65）（P值<0.0001）。
大多数CDGP患者未达到其靶身高或预测成年身高；他们通常比父母和一般人群矮。此类患者需要随访至达到最终身高，在某些情况下，可能需要辅助药物治疗。
