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青春期男性的青春期诱导：当前实践

Puberty Induction in Adolescent Males: Current Practice.

作者信息

Alenazi Mohammed S, Alqahtani Ali M, Ahmad Mohammad M, Almalki Eyad M, AlMutair Angham, Almalki Mussa

机构信息

Diabetes and Endocrine Treatment Center, Prince Sultan Military Medical City, Riyadh, SAU.

Obesity, Endocrine, and Metabolism Center, King Fahad Medical City, Riyadh, SAU.

出版信息

Cureus. 2022 Apr 5;14(4):e23864. doi: 10.7759/cureus.23864. eCollection 2022 Apr.

DOI:10.7759/cureus.23864
PMID:35530907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9073269/
Abstract

Puberty is a developmental stage characterized by the appearance of secondary sexual characteristics which leads to complete physical, psychosocial, and sexual maturation. The current practice of hormonal therapy to induce puberty in adolescent males is based on published consensus and expert opinion. Evidence-based guidelines on optimal timing and regimen in puberty induction in males are lacking, and this reflects some discrepancies in practice among endocrinologists. It is worth mentioning that the availability of various hormonal products in markets, their different routes of administration, and patients/parents' preference also have an impact on clinical decisions. This review outlines the current clinical approach to delayed puberty in boys with an emphasis on puberty induction.

摘要

青春期是一个发育阶段，其特征是出现第二性征，从而导致身体、心理社会和性方面的完全成熟。目前对青春期男性进行激素治疗以诱导青春期的做法是基于已发表的共识和专家意见。缺乏关于男性青春期诱导最佳时机和方案的循证指南，这反映出内分泌学家在实践中存在一些差异。值得一提的是，市场上各种激素产品的可得性、它们不同的给药途径以及患者/家长的偏好也会对临床决策产生影响。本综述概述了目前对青春期延迟男孩的临床处理方法，重点是青春期诱导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/b54b58db8069/cureus-0014-00000023864-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/bcbf69b34685/cureus-0014-00000023864-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/b2273560356d/cureus-0014-00000023864-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/88594f1c24c9/cureus-0014-00000023864-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/cc61f602fdb1/cureus-0014-00000023864-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/b54b58db8069/cureus-0014-00000023864-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/bcbf69b34685/cureus-0014-00000023864-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/b2273560356d/cureus-0014-00000023864-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/88594f1c24c9/cureus-0014-00000023864-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/cc61f602fdb1/cureus-0014-00000023864-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6306/9073269/b54b58db8069/cureus-0014-00000023864-i05.jpg

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J Pediatr Endocrinol Metab. 2020 Sep 25;33(9):1197-1202. doi: 10.1515/jpem-2020-0157.
2
Androgens During Infancy, Childhood, and Adolescence: Physiology and Use in Clinical Practice.婴儿期、儿童期和青春期的雄激素：生理学及在临床实践中的应用。
Endocr Rev. 2020 Jun 1;41(3). doi: 10.1210/endrev/bnaa003.
3
Testosterone Therapy in Adolescent Boys: The Need for a Structured Approach.
婴儿期小阴茎的早期管理可挽救成年后的性生活：一项综合综述。
World J Clin Pediatr. 2024 Jun 9;13(2):89224. doi: 10.5409/wjcp.v13.i2.89224.
4
A Current Perspective on Delayed Puberty and Its Management.青春期延迟及其管理的当前观点
J Clin Res Pediatr Endocrinol. 2024 Dec 4;16(4):379-400. doi: 10.4274/jcrpe.galenos.2024.2024-2-7. Epub 2024 Apr 29.
青少年男性的睾酮治疗：需要结构化方法。
Horm Res Paediatr. 2019;92(4):215-228. doi: 10.1159/000504670. Epub 2019 Dec 18.
4
Review of the Literature on Current Changes in the Timing of Pubertal Development and the Incomplete Forms of Early Puberty.关于青春期发育时间当前变化及青春期早熟不完全形式的文献综述
Front Pediatr. 2019 May 8;7:147. doi: 10.3389/fped.2019.00147. eCollection 2019.
5
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