Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Department of Neuroscience, Brown University, Providence, RI, United States.
Front Neural Circuits. 2018 Feb 5;12:5. doi: 10.3389/fncir.2018.00005. eCollection 2018.
The cerebrospinal fluid (CSF) occupies the brain's ventricles and subarachnoid space and, together with the interstitial fluid (ISF), forms a continuous fluidic network that bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned to actively distribute neuromodulators to neural circuits via volume transmission. Recent experimental work in brain slices and neuronal cultures has shown that human CSF indeed contains neuromodulators that strongly influence neuronal activity. Here we briefly summarize these new findings and discuss their potential relevance to neural circuits in health and disease.
脑脊液（CSF）占据了大脑的脑室和蛛网膜下腔，与细胞间液（ISF）一起形成了一个连续的流体网络，为中枢神经系统（CNS）的所有细胞提供了浸润环境。因此，脑脊液通过容积传递将神经调质积极地分配到神经回路中。最近在脑切片和神经元培养物中的实验工作表明，人脑脊液中确实含有神经调质，这些调质强烈影响神经元的活动。在这里，我们简要总结了这些新发现，并讨论了它们在健康和疾病的神经回路中的潜在相关性。
